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Denatonium benzoate, anidro ≥99.5%, granular NF

Fornitore: Spectrum Chemical
Descrizione: Denatonium Benzoate, Anhydrous, Granular, NF is used as a denaturant and masking agent.

Image Unavailable-SPCMHY123-125GM

Idrossipropilmetilcellulosa (Hypromellose), 100 mPa.s USP Substitution Type 2208

Codice catalogo: (SPCMHY123-125GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: HY123-125GM
Codice articolo locale: SPCMHY123-125GM
Descrizione: Hypromellose, Substitution Type 2208, 100 mPa.s, USP. 
UOM: 1 * 1 pezzi
Image Unavailable-SPCMMA140-12KG

Magnesium trisilicate, hydrate, in polvere USP

Fornitore: Spectrum Chemical
Descrizione: Magnesium Trisilicate, Powder, USP is a buffering agent excipient.

Image Unavailable-SPCMCH135-2.5KG

Colesterolo NF

Fornitore: Spectrum Chemical
Descrizione: BSE/TSE statement (available upon request) Allergen statement (available upon request)

Image Unavailable-SPCMCA184-100GM

Carbomer 934P resin, in polvere NF

Codice catalogo: (SPCMCA184-100GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: CA184-100GM
Codice articolo locale: SPCMCA184-100GM
Descrizione: Carbomer 934P, Resin, NF polymers can provide bioadhesion and good binding characteristics that provide highly effective controlled-release properties.
UOM: 1 * 100 g
Image Unavailable-SPCMC2052-12KG

Choline hydrogen tartrate USP dietary supplement

Fornitore: Spectrum Chemical
Descrizione: Choline Bitartrate, USP Dietary Supplement.

Image Unavailable-SPCMCA150-12KG

Calcio idrossido, in polvere USP, Ph. Eur., BP, JP

Fornitore: Spectrum Chemical
Descrizione: Kosher certified

MSDS

Image Unavailable-BOSSBS-6634R-CY3

Anti-XPC Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-6634R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-6634R-CY3
Codice articolo locale: BOSSBS-6634R-CY3
Descrizione: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-SPCMPO132-500MLGL

Polysorbate 20 NF

Codice catalogo: (SPCMPO132-500MLGL)
Fornitore: Spectrum Chemical
Codice articolo fornitore: PO132-500MLGL
Codice articolo locale: SPCMPO132-500MLGL
Descrizione: Polysorbate 20, NF is a hydrophilic, nonionic, polysorbate surfactant and a polyoxyethylene derivative of sorbitan monolaurate with relative non-toxicity.
UOM: 1 * 500 mL
Image Unavailable-BOSSBS-6634R-HRP

Anti-XPC Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-6634R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-6634R-HRP
Codice articolo locale: BOSSBS-6634R-HRP
Descrizione: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-SPCMS1420-500GM

Tetrasodium diphosphate decahydrate ≥99%, cristalli ACS

Codice catalogo: (SPCMS1420-500GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: S1420-500GM
Codice articolo locale: SPCMS1420-500GM
Descrizione: Sodium Pyrophosphate, Decahydrate, Crystal, Reagent, ACS is also known as tetrasodium pyrophosphate and is employed as a buffering agent as well as a thickening agent and can be found in many foods under the shape of a food additive. It is also used in toothpaste to aid in tartar control in the mouth. As an ACS grade quality reagent, its chemical specifications are the de facto standards for chemicals used in many high-purity applications and typically designate the highest quality chemical available for laboratory use. Spectrum Chemical manufactured Reagent ACS grade products meet the toughest regulatory standards for quality and purity.
UOM: 1 * 500 g
Image Unavailable-BOSSBS-15482R

Anti-hHR23b Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-15482R)
Fornitore: Bioss
Codice articolo fornitore: BS-15482R
Codice articolo locale: BOSSBS-15482R
Descrizione: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15482R-A555

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 555)

Codice catalogo: (BOSSBS-15482R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-15482R-A555
Codice articolo locale: BOSSBS-15482R-A555
Descrizione: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6634R-A350

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-6634R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-6634R-A350
Codice articolo locale: BOSSBS-6634R-A350
Descrizione: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-SPCMBE129-12KGBL

Benzetonio cloruro USP

Fornitore: Spectrum Chemical
Descrizione: Melamine statement (available upon request)
BSE/TSE statement (available upon request)
Allergen statement (available upon request)

Image Unavailable-SPCMS1023-1KG

L(+)-Serina USP

Fornitore: Spectrum Chemical
Descrizione: BSE/TSE statement (available upon request)
Allergen statement (available upon request)

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La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
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