Hai cercato: PP1

Fornitore: Apollo Scientific

Descrizione: PP1 free base ≥99%

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Src kinase inhibitor

New Product

Codice catalogo: (USBIP9107-20A)

Fornitore: US Biological

Codice articolo fornitore: P9107-20A

Codice articolo locale: USBIP9107-20A

Descrizione: Anti-PP1 gamma1 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

Promo

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Inhibitor of PP1 and PP2A

New Product

Codice catalogo: (BOSSBS-11666R)

Fornitore: Bioss

Codice articolo fornitore: BS-11666R

Codice articolo locale: BOSSBS-11666R

Descrizione: Eukaryotic protein phosphorylation and dephosphorylation on serine and threonine residues regulates numerous cell functions, including division, homeostasis and apoptosis. A group of proteins that play a major role in this process are the serine/threonine protein phosphatases. Protein phosphatase (PP) holoenzyme is a trimeric complex that contains a regulatory subunit, a variable subunit and a catalytic subunit. Families of PP catalytic subunits include PP1, PP2A, PP2B, PP2C, PPX and PP5. Regulatory subunits include nuclear inhibitor of PP1 (NIPP1), PP1 nuclear targeting subunit (PNUTS), PP2A-A, PP2A-B, PP2A-B56, PP2A-C, PP2B-B and PR48. PNUTS, also designated CAT53 or FB19, is encoded by the gene PPP1R10. PNUTS acts as an inhibitor for the phosphatase activity of PP1 Alpha and PP1 Gamma. It is a nuclear protein primarily detected in nucleoplasmic bodies and within nucleoli. PNUTS expression levels are highest in brain, heart, lung, placenta, liver, kidney, pancreas and skeletal muscle.

UOM: 1 * 100 µl

Promo

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Inhibitor of PP1 and PP2A

New Product

Codice catalogo: (ENZOALX350431C010)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: ALX350431C010

Codice articolo locale: ENZOALX350431C010

Descrizione: Inhibitor of PP1 and PP2A

UOM: 1 * 10 µG

New Product Promo

Codice catalogo: (BOSSBS-11988R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-11988R-A750

Codice articolo locale: BOSSBS-11988R-A750

Descrizione: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development. Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation. Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells. Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain. Neurabin II localizes to neuronal dentritic spines, which are the specialised protrusions from dendritic shafts that receive most of the excitatory input in the CNS. Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells. Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis. Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11988R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-11988R-A647

Codice articolo locale: BOSSBS-11988R-A647

Descrizione: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3658R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-3658R-CY5.5

Codice articolo locale: BOSSBS-3658R-CY5.5

Descrizione: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11988R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-11988R-CY7

Codice articolo locale: BOSSBS-11988R-CY7

Descrizione: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11988R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-11988R-A555

Codice articolo locale: BOSSBS-11988R-A555

Descrizione: Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons; it localizes in the growth cone lamellipodia during neuronal development (1). Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1). Neurabin I recruits active PP1 via a PP1-docking sequence; mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2,3). Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4). Neurabin II localizes to neuronal dentritic spines, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5). Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5). Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5). Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4).

UOM: 1 * 100 µl

Promo

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Inhibitor of PP1 and PP2A

New Product

Codice catalogo: (BOSSBS-3658R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-3658R-CY7

Codice articolo locale: BOSSBS-3658R-CY7

Descrizione: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3658R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-3658R-A750

Codice articolo locale: BOSSBS-3658R-A750

Descrizione: Inhibitor subunit of the major nuclear protein phosphatase 1 (PP1). It has RNA binding activity but does not cleave RNA and may target PP1 to RNA associated substrates. May also be involved in pre mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (APOSBIC1019-10UG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BIC1019-10UG

Codice articolo locale: APOSBIC1019-10UG

Descrizione: PP1 inhibitor, PP2 inhibitor, serine/threonine phosphatatase inhibitor.

UOM: 1 * 10 g

New Product Promo