Nodularin
Fornitore: ENZO LIFE SCIENCES AG
Inhibitor of PP1 and PP2A
Inhibitor of protein phosphatase 1 (PP1) (IC50=1.8nM), protein phosphatase 2A (PP2A) (IC50=0.026nM) and to a lesser extent protein phosphatase 2B (PP2B) (IC50=8.7µm). Similar to microcystin-LR (Prod. No. ALX-350-012) but with increased water solubility. Genotoxic. Hepatoxic. Induces oxidative DNA damage by oxidation of purines. Induces apoptosis in HepG2 cells.
Isolated from Nodularia spumigena.
Formula:
C₄₁H₆₀N₈O₁₀ Peso molecolare: 824,977 g/mol |
CAS Number:
118399-22-7 |
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