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Image Unavailable-BOSSBS-12394R-A555

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-12394R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A555
Codice articolo locale: BOSSBS-12394R-A555
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-A488

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-12394R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A488
Codice articolo locale: BOSSBS-12394R-A488
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5474R-HRP

Anti-MBP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-5474R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-5474R-HRP
Codice articolo locale: BOSSBS-5474R-HRP
Descrizione: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11238R-A680

Anti-SHANK2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-11238R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-11238R-A680
Codice articolo locale: BOSSBS-11238R-A680
Descrizione: SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localisation of ion channels, receptors, Signalling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11238R-CY7

Anti-SHANK2 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-11238R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-11238R-CY7
Codice articolo locale: BOSSBS-11238R-CY7
Descrizione: SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11238R-A647

Anti-SHANK2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-11238R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-11238R-A647
Codice articolo locale: BOSSBS-11238R-A647
Descrizione: SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
UOM: 1 * 100 µl
Image Unavailable-20441.

Anti-V5 Tag Rabbit Polyclonal Antibody (CF543)

Codice catalogo: (20441.)
Fornitore: Biotium
Codice articolo fornitore: 20441
Codice articolo locale: BTIU20441
Descrizione: Polyclonal anti-V5 (GKPIPNPLLGLDST) reacts with V5 tagged fusion proteins. The V5 epitope tag is derived from a small epitope (Pk) present on the P and V proteins of the paramyxovirus of simian virus 5 (SV5). The antibody recognizes the epitope tag fused to either the amino- or carboxy- termini of targeted proteins. Polyclonal anti-MYC (EQKLISEEDL) reacts with human c- MYC tagged fusion proteins. The antibody recognizes the epitope tag fused to either the amino- or carboxy- termini of targeted proteins. This conjugate is prepared by labeling polyclonal rabbit anti-MYC IgG (H+L) with CF™543 dye. CF™543 is an orange fluorescent dye with an excitation spectrum optimally matching the 543 laser line. Antibody conjugates of the dye are much brighter than those of Alexa Fluor® 546.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11955R-A680

Anti-SLITRK2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-11955R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-11955R-A680
Codice articolo locale: BOSSBS-11955R-A680
Descrizione: SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK2 (SLIT and NTRK-like protein 2) is a 845 amino acid single-pass type I membrane protein that contains 14 LRR (leucine-rich) repeats and is expressed in neural tissues, with highest levels found in adult cerebral cortex. Overexpression of SLITRK2 leads to inhibition of unipolar neurites in cultured cells, suggesting that it suppresses neurite outgrowth. Inhibitory activity of SLITRK2 is localised to its C-terminal intracellular domain and without this region the protein induces neurite outgrowth. Variants in the gene encoding SLITRK2 may contribute to the development of bipolar disorder, autism spectrum disorder and schizophrenia. There are two isoforms of SLITRK2 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11955R-HRP

Anti-SLITRK2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-11955R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-11955R-HRP
Codice articolo locale: BOSSBS-11955R-HRP
Descrizione: SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK2 (SLIT and NTRK-like protein 2) is a 845 amino acid single-pass type I membrane protein that contains 14 LRR (leucine-rich) repeats and is expressed in neural tissues, with highest levels found in adult cerebral cortex. Overexpression of SLITRK2 leads to inhibition of unipolar neurites in cultured cells, suggesting that it suppresses neurite outgrowth. Inhibitory activity of SLITRK2 is localized to its C-terminal intracellular domain and without this region the protein induces neurite outgrowth. Variants in the gene encoding SLITRK2 may contribute to the development of bipolar disorder, autism spectrum disorder and schizophrenia. There are two isoforms of SLITRK2 that are produced as a result of alternative splicing events.
UOM: 1 * 100 µl
Image Unavailable-BNC470253-100

Anti-KRT77 Mouse Monoclonal Antibody (CF647) [clone: AE-1]

Fornitore: Biotium
Descrizione: This MAb recognizes the 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40 kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52 kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.

Image Unavailable-BNC400253-100

Anti-KRT77 Mouse Monoclonal Antibody (CF640R) [clone: AE-1]

Fornitore: Biotium
Descrizione: This MAb recognizes the 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19) keratins of the acidic (Type I or LMW) subfamily. Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50', 48, 46, 45, and 40 kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52 kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.

Image Unavailable-BOSSBS-6273R-A488

Anti-ENO1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-6273R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-6273R-A488
Codice articolo locale: BOSSBS-6273R-A488
Descrizione: Enolase 1 is a multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.Enolase 2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.Enolase 3 appears to have a function in striated muscle development and regeneration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6273R-A555

Anti-ENO1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-6273R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-6273R-A555
Codice articolo locale: BOSSBS-6273R-A555
Descrizione: Enolase 1 is a multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.Enolase 2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.Enolase 3 appears to have a function in striated muscle development and regeneration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-CY5

Anti-DTX2 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-12394R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-CY5
Codice articolo locale: BOSSBS-12394R-CY5
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0399R-CY5

Anti-DTX1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-0399R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-0399R-CY5
Codice articolo locale: BOSSBS-0399R-CY5
Descrizione: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-A680

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-12394R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A680
Codice articolo locale: BOSSBS-12394R-A680
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch Signalling, a Signalling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
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