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Image Unavailable-BOSSBS-7144R-A350

Anti-ARHGEF18 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-7144R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-7144R-A350
Codice articolo locale: BOSSBS-7144R-A350
Descrizione: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2966R-A647

Anti-RBPJK Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-2966R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-2966R-A647
Codice articolo locale: BOSSBS-2966R-A647
Descrizione: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2966R-CY5

Anti-RBPJK Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-2966R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-2966R-CY5
Codice articolo locale: BOSSBS-2966R-CY5
Descrizione: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6335R-A750

Anti-ALOX15B Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-6335R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-6335R-A750
Codice articolo locale: BOSSBS-6335R-A750
Descrizione: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
UOM: 1 * 100 µl
Product Image-78445.

Halt™ Protease and Phosphatase Inhibitor Cocktail

Fornitore: Thermo Fisher Scientific
Descrizione: Halt protease and phosphatase inhibitor cocktail provides the convenience of a single solution with full sample protection. This broad-spectrum inhibitor cocktail is specifically optimised to protect proteins from degradation during extraction and purification. The cocktail contains inhibitors against the major classes of proteases and phosphatases, targeting aminopeptidases, cysteine and serine proteases and serine/threonine and protein tyrosine phosphatases.

Image Unavailable-BOSSBS-0399R-CY7

Anti-DTX1 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-0399R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-0399R-CY7
Codice articolo locale: BOSSBS-0399R-CY7
Descrizione: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
UOM: 1 * 100 µl
Image Unavailable-SPEC132294

Spectra/Por® Micro-dialysis Hollow Fibers

Codice catalogo: (SPEC132294)
Fornitore: Spectrum Laboratories
Codice articolo fornitore: 132294
Codice articolo locale: SPEC132294
Descrizione: The implantation of individual micro-dialysis hollow fibers is an ideal step in the recovery or introduction of micro-quantity biologicals or pharmaceutical materials in a localized tissue environment. Following sample injection into the lumen via syringe, the fiber ends may be sealed with epoxy for implantation.
UOM: 1 * 20 pezzi
Image Unavailable-BOSSBS-12394R-A555

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-12394R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A555
Codice articolo locale: BOSSBS-12394R-A555
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-A488

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-12394R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A488
Codice articolo locale: BOSSBS-12394R-A488
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5474R-HRP

Anti-MBP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-5474R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-5474R-HRP
Codice articolo locale: BOSSBS-5474R-HRP
Descrizione: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0399R-CY5.5

Anti-DTX1 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-0399R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-0399R-CY5.5
Codice articolo locale: BOSSBS-0399R-CY5.5
Descrizione: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
UOM: 1 * 100 µl
Image Unavailable-20437.

Anti-Myc Tag Rabbit Polyclonal Antibody (CF543)

Codice catalogo: (20437.)
Fornitore: Biotium
Codice articolo fornitore: 20437
Codice articolo locale: BTIU20437
Descrizione: Polyclonal anti-MYC (EQKLISEEDL) reacts with human c- MYC tagged fusion proteins. The antibody recognizes the epitope tag fused to either the amino- or carboxy- termini of targeted proteins.Polyclonal anti-MYC (EQKLISEEDL) reacts with human c- MYC tagged fusion proteins. The antibody recognizes the epitope tag fused to either the amino- or carboxy- termini of targeted proteins. This conjugate is prepared by labeling polyclonal rabbit anti-MYC IgG (H+L) with CF™543 dye. CF™543 is an orange fluorescent dye with an excitation spectrum optimally matching the 543 laser line. Antibody conjugates of the dye are much brighter than those of Alexa Fluor® 546.

Alexa Fluor® is a registered trademark of Thermo Fisher Scientific.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6273R-A750

Anti-ENO1+ENO2+ENO3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-6273R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-6273R-A750
Codice articolo locale: BOSSBS-6273R-A750
Descrizione: Enolase 1 is a multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor.Enolase 2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival.Enolase 3 appears to have a function in striated muscle development and regeneration.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-A750

Anti-DTX2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-12394R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-A750
Codice articolo locale: BOSSBS-12394R-A750
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch Signalling, a Signalling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12394R-HRP

Anti-DTX2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-12394R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-12394R-HRP
Codice articolo locale: BOSSBS-12394R-HRP
Descrizione: DTX2 belongs to the Deltex family. It contains one RING-type zinc finger and two WWE domains. DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context; mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. DTX2 also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases. There are two named isoforms.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0380R-HRP

Anti-MBP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-0380R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-0380R-HRP
Codice articolo locale: BOSSBS-0380R-HRP
Descrizione: Oligodendrocyte Marker The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
UOM: 1 * 100 µl
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