Hai cercato: N-Carbobenzoxy-L-tyrosine

Codice catalogo: (BOSSBS-1738R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1738R-A750

Codice articolo locale: BOSSBS-1738R-A750

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1738R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-1738R-A350

Codice articolo locale: BOSSBS-1738R-A350

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-FITC

Codice articolo locale: BOSSBS-12914R-FITC

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-A350

Codice articolo locale: BOSSBS-12914R-A350

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1738R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-1738R-A647

Codice articolo locale: BOSSBS-1738R-A647

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5400R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-5400R-CY7

Codice articolo locale: BOSSBS-5400R-CY7

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12916R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12916R-A350

Codice articolo locale: BOSSBS-12916R-A350

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12916R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12916R-FITC

Codice articolo locale: BOSSBS-12916R-FITC

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12916R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-12916R-CY7

Codice articolo locale: BOSSBS-12916R-CY7

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3089R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-3089R-A488

Codice articolo locale: BOSSBS-3089R-A488

Descrizione: The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL’s interaction with downstream targets of tyrosine kinases, such as PI 3K and Vav.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-CY5

Codice articolo locale: BOSSBS-13651R-CY5

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-A647

Codice articolo locale: BOSSBS-13651R-A647

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-A750

Codice articolo locale: BOSSBS-13651R-A750

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11834R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-11834R-A647

Codice articolo locale: BOSSBS-11834R-A647

Descrizione: Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Localized to the nucleus and highly expressed in testis, muscle and the developing nervous system, Dyrk1A, also known as MNB or MNBH, functions to phosphorylate serine, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation. Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), suggesting a possible role for Dyrk1A in the development of DS. Four isoforms of Dyrk1A exist due to alternative splicing events.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12574R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12574R-FITC

Codice articolo locale: BOSSBS-12574R-FITC

Descrizione: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12574R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-12574R-A647

Codice articolo locale: BOSSBS-12574R-A647

Descrizione: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

UOM: 1 * 100 µl

Promo