Hai cercato: N-Carbobenzoxy-L-tyrosine

Codice catalogo: (BOSSBS-12942R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12942R-A350

Codice articolo locale: BOSSBS-12942R-A350

Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12941R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12941R-FITC

Codice articolo locale: BOSSBS-12941R-FITC

Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Fornitore: TCI

Descrizione: (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid ≥98.0% (by HPLC, titration analysis)

Codice catalogo: (BOSSBS-11834R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-11834R-A647

Codice articolo locale: BOSSBS-11834R-A647

Descrizione: Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Localized to the nucleus and highly expressed in testis, muscle and the developing nervous system, Dyrk1A, also known as MNB or MNBH, functions to phosphorylate serine, threonine and tyrosine residues on various substrates involved in signaling pathways that regulate cell proliferation. Dyrk1A is a candidate gene for learning defects that are involved in Downs syndrome (DS), suggesting a possible role for Dyrk1A in the development of DS. Four isoforms of Dyrk1A exist due to alternative splicing events.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12941R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-12941R-A750

Codice articolo locale: BOSSBS-12941R-A750

Descrizione: All members of the Src gene family of tyrosine kinases are characterised by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5 to 10 fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8028R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-8028R-A555

Codice articolo locale: BOSSBS-8028R-A555

Descrizione: This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3463R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-3463R-CY7

Codice articolo locale: BOSSBS-3463R-CY7

Descrizione: Neuronal MarkerTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11645R)

Fornitore: Bioss

Codice articolo fornitore: BS-11645R

Codice articolo locale: BOSSBS-11645R

Descrizione: Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo; catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3463R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-3463R-FITC

Codice articolo locale: BOSSBS-3463R-FITC

Descrizione: Neuronal MarkerTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11066R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-11066R-A488

Codice articolo locale: BOSSBS-11066R-A488

Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11066R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-11066R-HRP

Codice articolo locale: BOSSBS-11066R-HRP

Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11066R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-11066R-CY7

Codice articolo locale: BOSSBS-11066R-CY7

Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6235R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6235R-CY3

Codice articolo locale: BOSSBS-6235R-CY3

Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6235R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-6235R-CY7

Codice articolo locale: BOSSBS-6235R-CY7

Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6235R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-6235R-CY5.5

Codice articolo locale: BOSSBS-6235R-CY5.5

Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3463R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-3463R-A680

Codice articolo locale: BOSSBS-3463R-A680

Descrizione: Neuronal MarkerTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

UOM: 1 * 100 µl

Promo