Hai cercato: N-Carbobenzoxy-L-tyrosine

Codice catalogo: (BOSSBS-6271R)

Fornitore: Bioss

Codice articolo fornitore: BS-6271R

Codice articolo locale: BOSSBS-6271R

Descrizione: Probable receptor with tyrosine-protein kinase activity; important for development.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5453R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-5453R-A647

Codice articolo locale: BOSSBS-5453R-A647

Descrizione: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2752R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A555

Codice articolo locale: BOSSBS-2752R-A555

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2752R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A750

Codice articolo locale: BOSSBS-2752R-A750

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Fornitore: TCI

Descrizione: Fmoc-L-Tyr(Me)-OH ≥98.0% (by HPLC, titration analysis)

Codice catalogo: (BOSSBS-12942R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12942R-A350

Codice articolo locale: BOSSBS-12942R-A350

Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12941R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12941R-FITC

Codice articolo locale: BOSSBS-12941R-FITC

Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Fornitore: Cayman Chemical

Descrizione: 3-(3,4-Dihydroxyphenyl)-L-alanine

MSDS

Codice catalogo: (BOSSBS-6850R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-6850R-CY5

Codice articolo locale: BOSSBS-6850R-CY5

Descrizione: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6271R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6271R-CY3

Codice articolo locale: BOSSBS-6271R-CY3

Descrizione: Probable receptor with tyrosine-protein kinase activity; important for development.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10406R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-10406R-CY3

Codice articolo locale: BOSSBS-10406R-CY3

Descrizione: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6850R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6850R-CY3

Codice articolo locale: BOSSBS-6850R-CY3

Descrizione: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12941R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-12941R-A750

Codice articolo locale: BOSSBS-12941R-A750

Descrizione: All members of the Src gene family of tyrosine kinases are characterised by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5 to 10 fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-CY3

Codice articolo locale: BOSSBS-12914R-CY3

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-A555

Codice articolo locale: BOSSBS-12914R-A555

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-A647

Codice articolo locale: BOSSBS-12914R-A647

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo