Hai cercato: Membrane+filtranti

Codice catalogo: (BOSSBS-11261R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-11261R-A750

Codice articolo locale: BOSSBS-11261R-A750

Descrizione: Syntaxins, a family of proteins involved in the fusion of synaptic vesicles with the plasma membrane, display broad tissue distribution and contain carboxy-terminal hydrophobic domains that direct themselves to their respective intracellular compartments. Synaptin 6 is a 255 amino acid protein that is widely expressed, with higher expression levels in brain, lung and kidney. This synaptin co-localizes with vesicle associated membrane protein (VAMP) 4 to tubular and vesicular membranes of the Golgi apparatus. The cytosolic domain of Syntaxin 6 reduces the rate on Glut4 reinternalisation upon insulin withdrawl and is involved in a memrane-trafficking process that removes Glut4 from traffic directed to the plasma membrane. Syntaxin 6 is upregulated in activated macrophages in conjunction with an increase in the secretion of cytokines. The delivery of microdomain-associated lipids and proteins to the cell surface is regulated by Syntaxin 6.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15466R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-15466R-A647

Codice articolo locale: BOSSBS-15466R-A647

Descrizione: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. The interaction with MFSD2A is apparently important for this process. Endogenous envelope proteins may have kept, lost or modified their original function during evolution but this one can still make pseudotypes with MLV, HIV-1 or SIV-1 virions and confer infectivity. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein mediates receptor recognition, while the transmembrane protein anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13695R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-13695R-CY3

Codice articolo locale: BOSSBS-13695R-CY3

Descrizione: The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10427R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-10427R-A750

Codice articolo locale: BOSSBS-10427R-A750

Descrizione: Synaptobrevins/VAMPs, syntaxins, and the 25 kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localisation, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8167R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-8167R-A680

Codice articolo locale: BOSSBS-8167R-A680

Descrizione: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7097R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-7097R-HRP

Codice articolo locale: BOSSBS-7097R-HRP

Descrizione: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion.Tissue specificity: Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2675R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-2675R-CY5.5

Codice articolo locale: BOSSBS-2675R-CY5.5

Descrizione: a-Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6644R)

Fornitore: Bioss

Codice articolo fornitore: BS-6644R

Codice articolo locale: BOSSBS-6644R

Descrizione: The sub-membraneous region at the postsynaptic membrane contains a number of proteins critical for receptor targeting. Gephyrin is a microtubule-associated protein highly expressed in brain and localized to neuronal postsynaptic membranes. Gephyrin is essential for the postsynaptic localization of the inhibitory glycine receptor and is thought to anchor the receptor to subsynaptic microtubules. The protein is expressed in most mammalian tissues with predominant expression in brain. At least five additional splice variants of Gephyrin ranging in molecular weight have been identified in rat and human brain tissue.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13110R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-13110R-A488

Codice articolo locale: BOSSBS-13110R-A488

Descrizione: Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11841R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-11841R-CY5

Codice articolo locale: BOSSBS-11841R-CY5

Descrizione: TOCA-1 is a 605 amino acid protein that localizes to the cytoplasm and the cytoskeleton, as well as to cytoplasmic vesicles and the cell membrane, and contains one FCH domain, one REM repeat and one SH3 domain. Existing as multiple alternatively spliced isoforms, TOCA-1 interacts with CDC42 and is required for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis. Additionally, TOCA-1 is involved in membrane invagination, tubule formation and Actin polymerization. The gene encoding TOCA-1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11345R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-11345R-CY7

Codice articolo locale: BOSSBS-11345R-CY7

Descrizione: ERCs (ERC1 and ERC2) also referred to as ELKS and CAST are related proteins which share an identical C-terminal sequence. They interact with the conserved RIM PDZ domain via an unusual PDZ binding motif. ERC2/CAST 1 is only expressed as a single RIM binding variant. All ERCs have been shown to interact with Rab6, a protein involved in membrane trafficking at the Golgi complex. The function of these proteins has not been determined yet. They may link Rab6 mediated non-neuronal membrane traffic at the Golgi complex to neuronal membrane traffic at the active zone executed via RIMs.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BNUM0097-50)

Fornitore: Biotium

Codice articolo fornitore: BNUM0097-50

Codice articolo locale: BTIUBNUM0097-50

Descrizione: This antibody recognizes an antigen associated with the nuclear membrane expressed in human cells. It can be used to stain the nuclear membrane in cell or tissue preparations and can be used as a marker of the nuclear membrane in subcellular fractions. It produces a ring pattern around the nucleus of cells of normal and malignant cells and may be used to stain the nuclear membrane of cells in fixed or frozen tissue sections. ,The nuclear envelope (also known as the perinuclear envelope, nuclear membrane, nucleolemma or karyotheca) is the double membrane of the nucleus that encloses genetic material in eukaryotic cells. It separates the contents of the nucleus (DNA in particular) from the cytosol (cytoplasm). Numerous nuclear pores are present on the nuclear envelope to facilitate and regulate the exchange of materials (for example, proteins and RNA) between the nucleus and the cytoplasm. The space between the two membranes that make up the nuclear envelope is called the perinuclear space (also called the perinuclear cisterna), and is usually about 20 - 40 nm wide. Each of the two membranes is composed of a lipid bilayer. The outer membrane is continuous with the rough endoplasmic reticulum. The inner membrane is erected upon the nuclear lamina, a network of intermediate filaments made of lamin, that plays a role in mitosis and meiosis. The type of lamins present are A, B1, B2, and C. The nuclear envelope may also play a role in the disposition of chromatin inside the nucleus. The lamina acts as a site of attachment for chromosomes. It also acts like a shield for the nucleus. During prophase in mitosis, the chromatids begin condensing to form chromosomes, and the nuclear envelope begins to disintegrate. During metaphase, the nuclear envelope is completely disintegrated, and the chromosomes can be pulled apart as chromatids by the spindle fibers.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BOSSBS-11190R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-11190R-CY3

Codice articolo locale: BOSSBS-11190R-CY3

Descrizione: C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 molecules. These polymerized C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1558R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-1558R-FITC

Codice articolo locale: BOSSBS-1558R-FITC

Descrizione: Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1558R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-1558R-HRP

Codice articolo locale: BOSSBS-1558R-HRP

Descrizione: Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9340R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-9340R-CY3

Codice articolo locale: BOSSBS-9340R-CY3

Descrizione: MARCH6 (Membrane associated RING finger protein 6) belongs to the MARCH family, which contains at least seven membrane associated RING-CH (MARCH)proteins. MARCH proteins are E3 ubiquitin ligases and are located to subcellular membranes.

UOM: 1 * 100 µl

Promo