Hai cercato: Biosensis

Codice catalogo: (BSENR-1392-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1392-50

Codice articolo locale: BSENR-1392-50

Descrizione: Neurofilaments are composed of three intermediate filament proteins: light (~68 kDa), medium (~160 kDa) and heavy (~200 kDa), which are involved in the maintenance of the neuronal caliber. Neurofilament light (NF68 or NF-L) is the most abundant of the three proteins.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENR-1379-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1379-50

Codice articolo locale: BSENR-1379-50

Descrizione: Neurofilaments can be defined as the intermediate or 10nm diameter filaments found in neuronal cells. They are composed a mixture of subunits which often includes the neurofilament triplet proteins, NF-L, NF-M and NF-H. Neurofilaments may also include peripherin, alpha-internexin, nestin and in some cases vimentin. Alpha-internexin is a ~66 kDa Class IV intermediate filament subunit expressed in large amounts early in neuronal development, but is downregulated in many neurons as development procedes. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENR-1396-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1396-50

Codice articolo locale: BSENR-1396-50

Descrizione: Enolase is a metalloenzyme that catayzes the reaction between 2-phospho-D-glycerate and phosphoenolpyruvate during glycolysis. Mammalian enolase is composed of 3 subunits; alpha, beta and gamma (Neuron-specific enolase). These subunits can form homodimers or heterodimers. The alpha/gamma heterodimer and the gamma/gamma homodimer are found primarily in neurons.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENR-104-100)

Fornitore: Biosensis

Codice articolo fornitore: R-104-100

Codice articolo locale: BSENR-104-100

Descrizione: FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. SIMILARITY: Belongs to the orexin family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENS-057-500)

Fornitore: Biosensis

Codice articolo fornitore: S-057-500

Codice articolo locale: BSENS-057-500

Descrizione: NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 500 µG

Promo

Codice catalogo: (BSENC-1533-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1533-100

Codice articolo locale: BSENC-1533-100

Descrizione: Peroxisome proliferator-activated receptor gamma (PPARG) is a nuclear hormone receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription (Ref: SWISSPROT).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENC-1532-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1532-100

Codice articolo locale: BSENC-1532-100

Descrizione: FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. SIMILARITY: Belongs to the orexin family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-072-100)

Fornitore: Biosensis

Codice articolo fornitore: R-072-100

Codice articolo locale: BSENR-072-100

Descrizione: CATALYTIC ACTIVITY: ATP + H2O = ADP + phosphate. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein (By similarity). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. SIMILARITY: Belongs to the cation transport ATPase (P-type) family. Type V subfamily.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-076-100)

Fornitore: Biosensis

Codice articolo fornitore: R-076-100

Codice articolo locale: BSENR-076-100

Descrizione: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine. SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-098-100)

Fornitore: Biosensis

Codice articolo fornitore: R-098-100

Codice articolo locale: BSENR-098-100

Descrizione: FUNCTION: Seems to promotes the survival of visceral and proprioceptive sensory neurons. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENC-1510-500)

Fornitore: Biosensis

Codice articolo fornitore: C-1510-500

Codice articolo locale: BSENC-1510-500

Descrizione: Leptin is secreted by white adipocytes and functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. Leptin also has several endocrine functions and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing (Ref: Entrez Gene).

UOM: 1 * 500 µl

Promo

Codice catalogo: (BSENC-1399-50)

Fornitore: Biosensis

Codice articolo fornitore: C-1399-50

Codice articolo locale: BSENC-1399-50

Descrizione: Peripherin is a class-III neuronal intermediate filament protein found in certain classes of neuron, most of which are located in the peripheral nervous system. Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. The HGNC name for this protein is PRPH. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENC-1373-50)

Fornitore: Biosensis

Codice articolo fornitore: C-1373-50

Codice articolo locale: BSENC-1373-50

Descrizione: Glial fibrillary acidic protein (GFAP) is approx. 50 kDa intra-cytoplasmic filamentous protein of the cytoskeleton in astrocytes. During the development of the central nervous system, it is a cell-specific marker that distinguishes astrocytes from other glial cells. GFAP immunoreactivity has been shown in immature oligodendrocytes, epiglottic cartilage, pituicytes, papillary meningiomas, myoepithelial cells of the breast and in non-CNS: Schwann cells, salivary gland neoplasms, enteric glia cells, and metastasizing renal carcinomas.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENC-1523-500)

Fornitore: Biosensis

Codice articolo fornitore: C-1523-500

Codice articolo locale: BSENC-1523-500

Descrizione: Hormone Sensitive Lipase (HSL) hydrolyzes stored triglycerides to free fatty acids in adipose tissue and heart. In steroidogenic tissues, HSL principally converts cholesteryl esters to free cholesterol for steroid hormone production (ref: SWISSPROT).

UOM: 1 * 500 µl

Promo

Codice catalogo: (BSENM-1387-50)

Fornitore: Biosensis

Codice articolo fornitore: M-1387-50

Codice articolo locale: BSENM-1387-50

Descrizione: Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENC-1517-500)

Fornitore: Biosensis

Codice articolo fornitore: C-1517-500

Codice articolo locale: BSENC-1517-500

Descrizione: BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 500 µl

Promo