Hai cercato: Biosensis

Codice catalogo: (BSENM-377-100)

Fornitore: Biosensis

Codice articolo fornitore: M-377-100

Codice articolo locale: BSENM-377-100

Descrizione: Fox3 is one of a family of mammalian homologues of Fox-1. The Fox proteins are about 46kDa in size, and each includes a central highly conserved RRM type RNA recognition motif. Much interest has focused on Fox3 as a result of the recent finding that this protein corresponds to NeuN, a neuronal nuclear antigen. NeuN/Fox-3 has a function in RNA splicing and is expressed heavily and specifically in neuronal nuclei and cytoplasm. Our antibody was raised against the N-terminal 100 amino acids of human Fox3 as expressed in and purified from E. coli. We did not use full length Fox3 as immunogen since the three mammalian Fox homologues, namely Fox1, Fox2 and Fox3, include virtually identical RRM motifs. The N-terminal region of the three molecules are much more variable in the three molecules so antibodies specific for each of the three molecules can therefore be generated.

UOM: 1 * 100 µl

Promo

Fornitore: Biosensis

Descrizione: The Biosensis ApoE/Aβ Complex ELISA kit is a sandwich ELISA that allows the preferential measurement of ApoE/Aβ complexes. This kit consists of a pre-coated mouse monoclonal anti-Aβ capture antibody, a highly validated ApoE/Aβ complex standard that is pre-formed, lyophilised and ready for reconstitution, a biotinylated ApoE detection antibody, and horseradish peroxidase (HRP)-conjugated streptavidin and detection reagent. The addition of a substrate (3,3’,5,5’-tetramethylbenzidine, TMB) yields a coloured reaction product which is directly proportional to the level of ApoE/Aβ complex present in samples and protein standards. Importantly, a well-characteriaed and unique ApoE/Aβ complex is included as a standard. This complex is pre-formed and lyophilised, requiring only reconstitution with assay diluent prior to use.

Fornitore: Biosensis

Descrizione: The Biosensis Mature BDNF Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of BDNF in less than 3 hours in cell culture supernatants, serum, plasma (citrate and EDTA), cell lysates, human milk and brain extracts only if used as directed, with a simplified protocol and no loss of sensitivity or specificity.

Fornitore: Biosensis

Descrizione: The Biosensis proNGF Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of full-length proNGF protein in less than 4 hours in human serum, heparin-plasma, cell supernatants and lysates only if used as directed.

Fornitore: Biosensis

Descrizione: The Biosensis proBDNF Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the specific, fast and reliable quantification of proBDNF in less than 4 hours in cell culture supernatants, cell lysates, serum, citrate-plasma and tissue extracts only if used as directed.

Codice catalogo: (BSENR-1651-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1651-100

Codice articolo locale: BSENR-1651-100

Descrizione: GAP43 is very abundant protein which is found concentrated in neurons. One group discovered it as one of three proteins which becomes unregulated during the regeneration of the toad optic nerve (1). Three GAPs (Growth associated proteins) were discovered, and the number 43 comes from the apparent SDS-PAGE molecular weight of the one named GAP43. The HGNC name for this protein is, not surprisingly, GAP43. Later work showed that GAP43 does not run on SDS-PAGE in a fashion which accurately reflects its molecular weight, and that GAP43 proteins from different species may run at different apparent molecular weights. Partly due to these features GAP43 were independently discovered by several different groups and therefore has several alternate names, such as protein F1, pp46, neuromodulin, neural phosphoprotein B-50 and calmodulin-binding protein P-57. In each case the number reflects the apparent SDS-PAGE molecular weight, and underlines the unusual properties of this molecule. Mammalian GAP43 proteins contains only 226-243 amino acids, and so the real molecular weight is 23.61-25.14 kDa. GAP43 has been extensively studied and is known to be a major protein kinase C substrate and to bind calmodulin avidly. GAP43 is anchored to the plasma membrane by palmitoylation modifications.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-1381-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1381-100

Codice articolo locale: BSENR-1381-100

Descrizione: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. MMP2 isoform 2 mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. Catalytic activity of MMP2 causes cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln. (Ref: uniprot.org).

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-1717-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1717-50

Codice articolo locale: BSENR-1717-50

Descrizione: Anti-TrkB (phospho Y816/Y817) Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENM-1689-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1689-100

Codice articolo locale: BSENM-1689-100

Descrizione: Anti-LMNA Mouse T4 Antibody [clone: 4C4]

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1646-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1646-100

Codice articolo locale: BSENM-1646-100

Descrizione: Anti-ACTA Mouse T4 Antibody [clone: 5J11]

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-027-50-AT)

Fornitore: Biosensis

Codice articolo fornitore: M-027-50-AT

Codice articolo locale: BSENM-027-50-AT

Descrizione: Anti-TNR16 Mouse Monoclonal Antibody [clone: Clone: Me20.4] (Atto 488)

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENTR-150-FJB)

Fornitore: Biosensis

Codice articolo fornitore: TR-150-FJB

Codice articolo locale: BSENTR-150-FJB

Descrizione: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The fluorescent dye Fluoro-Jade® B (FJB), like its more purified brother Fluoro-Jade® C (FJC), is an anionic fluorescein derivative useful for the histological staining of neurons undergoing degeneration.

UOM: 1 * 30 mg

Promo

Codice catalogo: (BSENM-1727-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1727-100

Codice articolo locale: BSENM-1727-100

Descrizione: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (Ref: uniprot.org). ProGDNF is the unprocessed precursor molecule of mature GDNF and exists as homodimer.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1802-50)

Fornitore: Biosensis

Codice articolo fornitore: M-1802-50

Codice articolo locale: BSENM-1802-50

Descrizione: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Ref: uniprot.org

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENR-1794-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1794-100

Codice articolo locale: BSENR-1794-100

Descrizione: Beta-casein has an important role in determination of the surface properties of the casein micelles. it is cleaved into 3 chains (casoparan, casohypotensin and antioxidant peptide). Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. Casohypotensin acts as a bradykinin-potentiating peptide and induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. Antioxidant peptide has antioxidant activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENBEK-2240-2P)

Fornitore: Biosensis

Codice articolo fornitore: BEK-2240-2P

Codice articolo locale: BSENBEK-2240-2P

Descrizione: The Biosensis Mature BDNF/proBDNF Combo RapidTM enzyme-linked immunosorbent assay (ELISA) Kit combines individual, but complementary ELISA kits for the two most important BDNF isoforms: Mature BDNF (BSENBEK-2211) and full-length proBDNF (BSENBEK-2217).

UOM: 1 * 192 Tests

Promo