Hai cercato: Biosensis

Codice catalogo: (BSENM-1744-50)

Fornitore: Biosensis

Codice articolo fornitore: M-1744-50

Codice articolo locale: BSENM-1744-50

Descrizione: BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENM-1309-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1309-100

Codice articolo locale: BSENM-1309-100

Descrizione: The Human influenza hemagglutin (HA) tag corresponds to a region (98-106 amino acids) from the HA molecule.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1736-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1736-100

Codice articolo locale: BSENM-1736-100

Descrizione: BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENC-1534-500)

Fornitore: Biosensis

Codice articolo fornitore: C-1534-500

Codice articolo locale: BSENC-1534-500

Descrizione: Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).

UOM: 1 * 500 µl

Promo

Codice catalogo: (BSENR-1500-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1500-50

Codice articolo locale: BSENR-1500-50

Descrizione: The hormone Atrial natriuretic peptide (ANP) is produced by cardiomyocites and is secreted into the bloodstream. ANP acts on convoluted tubules in kidney reducing sodium absorption which results in reducing the blood pressure.

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENM-1719-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1719-100

Codice articolo locale: BSENM-1719-100

Descrizione: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer (Reference: www.uniprot.com).

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENC-1386-50)

Fornitore: Biosensis

Codice articolo fornitore: C-1386-50

Codice articolo locale: BSENC-1386-50

Descrizione: Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. This antibody binds primarily to the phosphorylated axonal forms of NF-H.

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENM-1320-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1320-100

Codice articolo locale: BSENM-1320-100

Descrizione: Recognizes native and denatured forms of Green Fluorescent Protein (GFP) and its variants: Enhanced Green Fluorescent Protein (EGFP), Yellow Fluorescent Protein (YFP), Enhanced Yellow Fluorescent Protein (EYFP) and Cyan Fluorescent Protein (CFP).

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-1556-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1556-100

Codice articolo locale: BSENR-1556-100

Descrizione: The elF2c (Argonaute, Ago) protein is a core protein of the RNA-induced silencing complex (RISC).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENM-1797-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1797-100

Codice articolo locale: BSENM-1797-100

Descrizione: Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Ref: uniprot.org

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1249-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1249-100

Codice articolo locale: BSENM-1249-100

Descrizione: X63 is a control mouse IgG antibody with no known reactivity. The antibody has been used successfully a negative control in westerns, all forms of IHC, IP and FACS

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-075-100)

Fornitore: Biosensis

Codice articolo fornitore: R-075-100

Codice articolo locale: BSENR-075-100

Descrizione: Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. FUNCTION: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. TISSUE SPECIFICITY: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.SUBUNIT: Soluble monomer which can form filamentous aggregates. Interacts with UCHL1. Interacts with phospholipase D and histones. SUBCELLULAR LOCATION: Cytoplasm. Membrane. Nucleus. Note=Membrane-bound in dopaminergic neurons. Also found in the nucleus. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist.

UOM: 1 * 100 µl

Promo

Fornitore: Biosensis

Descrizione: The Biosensis Mouse and Rat proNGF Rapid enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the quantification of rodent full-length proNGF protein in less than 4 hours in cell culture supernatants, cell lysates and tissue homogenates only if used as directed. This ELISA Kit has also successfully been used on mouse urine samples (Ryu JC et al., 2018). Please refer to the kit protocol for specific use instructions for each substrate application.

This ELISA kit contains a recombinant mouse proNGF standard expressed in E.coli and consists of a pre-coated anti-proNGF capture antibody, a biotinylated anti-proNGF detection antibody and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3',5,5'-tetramethylbenzidine, TMB) yields a colored reaction product which is directly proportional to the concentration of proNGF present in samples and protein standards. A proNGF positive control (QC sample) is provided to assure consistent assay performance. This ELISA kit detects rat proNGF due to high degree of homology (96%) with mouse proNGF based on amino acid sequence, and the ability of this kit in detecting proNGF in rat PC12 cell lysates and rat brain tissue homogenate. In the absence of a true rat proNGF standard, results may be expressed as 'mouse proNGF equivalents'. This ELISA kit shows only 20% reactivity with the human form of proNGF and is therefore not suitable to quantify human proNGF. No cross-reactivity was observed with mature mouse NGF and full-length proBDNF when tested in assay buffer.

The antibodies used in this ELISA kit bind epitopes within the pro-domain (capture) and mature domain (detection) of the protein, thus this ELISA assay does not detect the pro-domain peptide. This kit has not been tested for other applications. Sufficient amount of proNGF standard is supplied to allow for spike- and recovery experiments in order to validate this ELISA assay for other sample matrices if required.

Fornitore: Biosensis

Descrizione: The Biosensis NGFR/p75ECD Rapid™ enzyme-linked immunosorbent assay (ELISA) kit is a sandwich ELISA that allows the quantification of the extracellular domain (ECD) of mouse p75 neurotrophin receptor in less than 4 hours in cell culture supernatants and urine only if used as directed.

Codice catalogo: (BSENR-1502-50)

Fornitore: Biosensis

Codice articolo fornitore: R-1502-50

Codice articolo locale: BSENR-1502-50

Descrizione: Somatostatin is secreted by neuroendocrine neurons in hypothalamus and interacts with somatostatin receptors inhibiting secretion of somatotropin.

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENM-1692-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1692-100

Codice articolo locale: BSENM-1692-100

Descrizione: Anti-HSPB1 Mouse T4 Antibody [clone: 6H11]

UOM: 1 * 100 µG

Promo