Hai cercato: Aluminon

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Aluminon, Supelco®

Codice catalogo: (1.00128.0010)

Fornitore: Merck

Codice articolo fornitore: 1.00128.0010

Codice articolo locale: MERC1.00128.0010

Descrizione: Aluminon, Supelco®

UOM: 1 * 10 g

MSDS Promo

Non disponibile confezione

Descrizione: Reagent for aluminium. Aurintricarboxylic acid readily polymerises in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca²⁺ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca²⁺-activated protease that is activated during apoptosis.