Hai cercato: 3,5-Diiodo-L-tyrosine+dihydrate

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Olomoucine ≥98%, purissimo

Codice catalogo: (ENZOALX350013M025)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX350013M025

Codice articolo locale: ENZOALX350013M025

Descrizione: Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

UOM: 1 * 25 mg

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1,3-Diiodo-5,5-dimethylhydantoin ≥97.0% (by titrimetric analysis)

Fornitore: TCI

Descrizione: 1,3-Diiodo-5,5-dimethylhydantoin ≥97.0% (by titrimetric analysis)

4,5-Diiodo-3-methyl-1H-pyrazole

Fornitore: Apollo Scientific

Descrizione: 4,5-Diiodo-3-methyl-1H-pyrazole

Anti-MTMR2 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-11733R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-11733R-CY3

Codice articolo locale: BOSSBS-11733R-CY3

Descrizione: Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.

UOM: 1 * 100 µl

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