Hai cercato: Brefeldin A

Fornitore: Cayman Chemical

Descrizione: Brefeldin A

Fornitore: Apollo Scientific

Descrizione: BFA is a macrolide antiobiotic. Disrupts mechanism of Golgi apparatus.

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: GEF inhibitor

New Product

Fornitore: TCI EUROPE

Descrizione: Brefeldin A ≥98.0% (by HPLC)

Fornitore: Thermo Scientific

Descrizione: Brefeldin A (naturale)

MSDS

Codice catalogo: (203729-1)

Fornitore: Merck Millipore (Calbiochem‎)

Codice articolo fornitore: 203729-1

Codice articolo locale: CALB203729-1

Descrizione: Brefeldin A, Millipore®

UOM: 1 * 1 mg

Promo

Fornitore: Thermo Scientific

Descrizione: Brefeldin A ≥99%

MSDS Certificati

Fornitore: MP Biomedicals

Descrizione: Storage: Store at -20 °C.
Brefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. Produced by Penicillium brefeldianum. Blocks binding of the cytosolic coat protein b-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into post-Golgi compartments. It activates the sphingomyelin cycle. Brefeldin A mediated apoptosis has been observed in human tumor cells.
Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.