Hai cercato: Anticorpi

Codice catalogo: (BOSSBS-5904R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-5904R-A647

Codice articolo locale: BOSSBS-5904R-A647

Descrizione: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0250R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-0250R-CY5.5

Codice articolo locale: BOSSBS-0250R-CY5.5

Descrizione: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0250R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-0250R-A647

Codice articolo locale: BOSSBS-0250R-A647

Descrizione: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9461R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-9461R-A680

Codice articolo locale: BOSSBS-9461R-A680

Descrizione: The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate and establishing boundaries of gene expression. Notch Signalling activates the Hairy/Enhancer of split (HES) genes, which encode basic helix-loop-helix (bHLH) transcriptional repressors that are critical for directing embryonic patterning and development. The Hairy-related transcription factors (HRTs) comprise a subclass of bHLH proteins that exhibit structural similarity with the HES proteins and include HRT1, HRT2 and HRT3. The HRT family (also designated Hesr, Hey, CHF and Gridlock) contain a bHLH domain, an Orange domain and a novel YRPW domain, which is absent in HRT3. The Hairy-related genes map to human chromosomes 8q21, 6q21 and 1p34.3 for HRT1, HRT2 and HRT3, respectively, and are downstream targets for Notch Signalling. HRT1 is expressed in the somitic mesoderm, central nervous system, kidney, heart, nasal epithelium and limb buds in murine embryos as well as in adult tissues. It has altered expression in many breast, lung and kidney tumours. Like HRT1, HRT2 and HRT3 are also expressed in developing somites, heart and nervous system.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12212R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-12212R-A647

Codice articolo locale: BOSSBS-12212R-A647

Descrizione: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the Krüppel C2H2-type zinc-finger protein family, ZNF342 (zinc finger protein 342), also known as Zinc finger protein 296, is a 475 amino acid nuclear protein that contains six C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12491R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-12491R-CY7

Codice articolo locale: BOSSBS-12491R-CY7

Descrizione: Apolipoproteins are protein components of plasma lipoproteins. Apolipoprotein A-I (ApoA1) promotes cholesterol efflux from tissues to the liver for excretion. ApoA1 is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase, which is responsible for the formation of most plasma cholesteryl esters. AI-BP (Apolipoprotein A-I-binding protein), also known as YjeF N-terminal domain-containing protein 1, is a 288 amino acid secreted protein that binds ApoA1, ApoA2 and HDL. Individuals with impaired renal function show an increased rate of AI-BP excretion, indicating that it is normally reabsorbed within the kidney tubules. AI-BP belongs to the YjeF N-terminal domain protein family, which includes proteins that are frequently involved in oogenesis and spermatogenesis. There are two isoforms of AI-BP that are produced as a result of alternative splicing events.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10059R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-10059R-CY5

Codice articolo locale: BOSSBS-10059R-CY5

Descrizione: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2751R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-2751R-CY3

Codice articolo locale: BOSSBS-2751R-CY3

Descrizione: Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Aurora B is a mitotic protein kinase that phosphorylates histone H3 (probably on Serine 10), behaves as a chromosomal passenger protein, and may regulate several stages of mitosis such as centrosome separation, chromosome segregation and cytokinesis. It localizes to the inner centromere region from prophase to anaphase. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13742R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-13742R-CY5

Codice articolo locale: BOSSBS-13742R-CY5

Descrizione: Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4538R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4538R-HRP

Codice articolo locale: BOSSBS-4538R-HRP

Descrizione: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7062R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-7062R-A680

Codice articolo locale: BOSSBS-7062R-A680

Descrizione: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription <i>in vitro</i> (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11760R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-11760R-HRP

Codice articolo locale: BOSSBS-11760R-HRP

Descrizione: Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. KIAA0415 is a 807 amino acid protein that exists as three alternatively spliced isoforms. The KIAA0415 gene product has been provisionally designated KIAA0415 pending further characterization.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11760R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-11760R-FITC

Codice articolo locale: BOSSBS-11760R-FITC

Descrizione: Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. KIAA0415 is a 807 amino acid protein that exists as three alternatively spliced isoforms. The KIAA0415 gene product has been provisionally designated KIAA0415 pending further characterization.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6834R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-6834R-A488

Codice articolo locale: BOSSBS-6834R-A488

Descrizione: This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3822R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-3822R-A647

Codice articolo locale: BOSSBS-3822R-A647

Descrizione: Cyclin G2 may play a role in growth regulation and in negative regulation of cell cycle progesssion. Cyclin G2 expression levels increase through the cell cycle to peak in the mid/late-S phase and decrease during G2/M phase. It may also contribute in maintaining the quiescent state of differentiated cells. Cyclin G2 is similar to cyclin A in the cyclin box, although no kinase activity is detected.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7714R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-7714R-A750

Codice articolo locale: BOSSBS-7714R-A750

Descrizione: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organisation of stable microtubule binding sites in the outer plate of the kinetochore.

UOM: 1 * 100 µl

Promo