Hai cercato: Shenandoah Biotechnology

Fornitore: Shenandoah Biotechnology

Descrizione: Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.

Fornitore: Shenandoah Biotechnology

Descrizione: Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

Fornitore: Shenandoah Biotechnology

Descrizione: Growth differentiation factor 15 (GDF-15) is a member of the transforming growth factor beta (TGF-β) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions  during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs.

Fornitore: Shenandoah Biotechnology

Descrizione: CD40 ligand (CD40L) or CD154 is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.

Fornitore: Shenandoah Biotechnology

Descrizione: Resistin-like molecule-alpha (RELM-α) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). RELM-α and Resistin are secreted by adipocytes, unlike RELM-β which is secreted by gastrointestinal epithelial cells, and RELM-γ which is expressed by peripheal blood granulocytes and bone marrow cells.

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.

Fornitore: Shenandoah Biotechnology

Descrizione: Omentin is an adipokine that is produced and secreted by the small intestine, visceral adipose tissue, perivascular adipose tissue, and epicardial adipose tissue. Omentin enhances insulin-stimulated glucose uptake in adipocytes and is a link between obesity and Type 2 Diabetes. Omentin also functions as a vasodilator and plays a protective role during coronary atherosclerosis and hypertension.

Fornitore: Shenandoah Biotechnology

Descrizione: Fibroblast growth factor 10 (FGF-10) is a growth factor that is important during embryonic development, especially during lung, limb, brain, heart, and kidney morphogenesis.FGF-10 is expressed in mesenchymal cells and facilitates epithelial-mesenchymal signaling through binding the epithelially expressed FGF receptor 2b (FGFR2b). FGF-10 also functions as a mitogen for keratinising epidermal cells, and induces the migration and invasion of cancer cells.

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Fornitore: Shenandoah Biotechnology

Descrizione: WNT1-inducible-signaling pathway protein 2 (WISP-2) is a member of the CYR61/CTGF/NOV (CCN) family of regulatory factors. WISP-2 is expressed in ectodermal, mesodermal, and endodermal lineages, including primary osteoblasts, fibroblasts, mesenchymal stem cells, and adipogenic precursor cells. WISP-2 is a canonical WNT ligand that regulates cell proliferation, adhesion, and metastasis. Secreted WISP-2 promotes mesenchymal precursor cell proliferation and maintains them in an undifferentiated state. In bone-forming osteoblasts, WISP-2 promotes osteoblast adhesion and inhibits osteocalcin production.

Fornitore: Shenandoah Biotechnology

Descrizione: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS). TNF-α signal activation occurs through two receptors, TNFR1 and TNFR2. TNFR1 is expressed on most cell types, unlike TNFR2, which is expressed mainly on immune cells. TNF-α functions to stimulate phagocytosis in macrophages, chemoattract neutrophils, increase insulin resistance, and induce fever.

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage inflammatory protein-1 alpha (MIP-1 α), also known as CCL3, is a cytokine produced by macrophages. MIP-1 α binds the chemokine receptors CCR1, CCR4, and CCR5 to induce inflammatory responses, including the recruitment of granulocytes and neutrophil superoxide production. The MIP-1 α and MIP-1 β heterodimer exhibits antiviral activity against the human immunodeficiency virus 1 (HIV-1).