Hai cercato: Shenandoah Biotechnology

Fornitore: Shenandoah Biotechnology

Descrizione: Regulated upon activation, normal T cell expressed and secreted (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after T cell activation. RANTES signals through G protein-coupled receptors CCR5, CCR3, CCR1, and through the human CMV-encoded viral receptor US28. RANTES functions to recruit immune cells to inflammatory sites.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage Inflammatory Protein 2 (MIP-2), also known as CXCL2, is a small cytokine that is secreted by monocytes and neutrophils at sites of inflammation. MIP-2 functions through the chemokine receptor CXCR2 to act as a chemotactic agent for leukocytes and hematopoietic cells.

Fornitore: Shenandoah Biotechnology

Descrizione: Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3 β shows activity on mouse cells.

Fornitore: Shenandoah Biotechnology

Descrizione: Monocyte chemotactic protein 2 (MCP-2), also known as CCL8, is a cytokine that is important during allergic and inflammatory responses. MCP-2 activates mast cells, eosinophils, and basophils through the G protein-coupled chemokine receptors CCR1, CCR2B, and CCR5. MCP-2 signaling through the CCR5 receptor also functions as a natural inhibitor of the human immunodeficiency virus, type 1 (HIV-1).

Fornitore: Shenandoah Biotechnology

Descrizione: SCF is a multipotent factor which affects cells of the myeloid, erythroid, mast, and lymphoid lineages.

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Fornitore: Shenandoah Biotechnology

Descrizione: Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.

Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Fornitore: Shenandoah Biotechnology

Descrizione: Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

Codice catalogo: (SHBTPB-500-20)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-20

Codice articolo locale: SHBTPB-500-20

Descrizione: Cytokines for cell culture of mouse glioma cells. A glioma is a generic term used to describe tumors that arise from the glia tissue of the brain that supports and surrounds neurons. Glioma tumor cells can be successfully cultured <i>ex vivo</i> with EGF, FGF-basic (or FGF-2), and PDGFs (AA and BB).

UOM: 1 * 1 KIT

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Codice catalogo: (SHBT100-37AF-200UG)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: 100-37AF-200UG

Codice articolo locale: SHBT100-37AF-200UG

Descrizione: Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

UOM: 1 * 200 µG

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Codice catalogo: (SHBTPB-500-15)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-15

Codice articolo locale: SHBTPB-500-15

Descrizione: Cytokines for mouse neuronal cell culture. Neural Stem Cells (NSC) are self-renewing cells, of the neural lineage, capable of generating neurons (GABA, dopamine and motor neurons), astrocytes and oligodenrocytes. NSCs are marked by expression of Nestin and can be derived from fetal neural stem cells, adult neural stem cells, embryonic stem cells and adult somatic cells.

UOM: 1 * 1 KIT

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Codice catalogo: (SHBTPB-500-13)

Fornitore: Shenandoah Biotechnology

Codice articolo fornitore: PB-500-13

Codice articolo locale: SHBTPB-500-13

Descrizione: Cytokines for polarizing mouse T cells into Th17 cells. T helper 17 cells (Th17) are a distinct type of T cell subset that are thought to be important in immunity against microbes at the epitilial and mucosal interfaces of the body. Disruption of the regular function or balance of Th17 cells is thought to be involved in several autoimmune diseases and/or opportunistic infections. Th17 cells are characterized by their ability to produce IL-17, IL-22 and IL-21. Th17 cells can be cultured from naive CD4+ T cells by culturing them in the presence of anti-CD3 and anti-CD28 stimulation with recombinant IL-6 and recombinant TGF-β 1.

UOM: 1 * 1 KIT

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Fornitore: Shenandoah Biotechnology

Descrizione: Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates. There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors. SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division.

Fornitore: Shenandoah Biotechnology

Descrizione: IL-15 is a widely expressed proinflammatory cytokine that is structurally and functionally related to IL-2.

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Fornitore: Shenandoah Biotechnology

Descrizione: Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.