Hai cercato: ProSci Inc.

Codice catalogo: (PRSI92-299)

Fornitore: ProSci Inc.

Codice articolo fornitore: 92-299

Codice articolo locale: PRSI92-299

Descrizione: neuregulin-1 (heregulin-1，NRG1) is a member of neuregulin family, which is comprised of four genes that encode a large number of secreted or membrane-bound isoforms. All family members share an EGF-like domain that interacts with the ErbB family of tyrosine kinase receptors. NRG1 isoforms can be classified into type I, type II and type III isoforms. NRG1 directs ligand for ERBB3 and ERBB4 tyrosine kinase receptors, concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG proteins show distinct spatial and temporal expression patterns and play important roles during development of both the nervous system and the heart.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI35-574)

Fornitore: ProSci Inc.

Codice articolo fornitore: 35-574

Codice articolo locale: PRSI35-574

Descrizione: Anti-YFV Mouse Monoclonal Antibody

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI3493)

Fornitore: ProSci Inc.

Codice articolo fornitore: 3493

Codice articolo locale: PRSI3493

Descrizione: Raptor Antibody: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR activity resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. Raptor (regulatory associated protein of TOR) is a TOR-binding protein essential for TOR signaling in vivo. It acts as a TOR scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation. These substrates include the ribosomal protein S6 kinase (RP S6K) and the eukaryotic initiation factor 4E binding protein 4EBP1, proteins necessary for cell growth and proliferation and responsive to nutrient and mitogen levels. Raptor binds these proteins through a common 5 amino acid TOR-signaling (TOS) motif; mutation of this motif prevents the TOR-dependent phosphorylation of these proteins.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI26-781)

Fornitore: ProSci Inc.

Codice articolo fornitore: 26-781

Codice articolo locale: PRSI26-781

Descrizione: ASB6 belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI26-969)

Fornitore: ProSci Inc.

Codice articolo fornitore: 26-969

Codice articolo locale: PRSI26-969

Descrizione: R3HDM2 contains 1 R3H domain. The function of R3HDM2 remains unknown.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI35-126)

Fornitore: ProSci Inc.

Codice articolo fornitore: 35-126

Codice articolo locale: PRSI35-126

Descrizione: Anti-Canine Heartworm Goat Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

UOM: 1 * 1 mL

Promo

Codice catalogo: (PRSI32-185)

Fornitore: ProSci Inc.

Codice articolo fornitore: 32-185

Codice articolo locale: PRSI32-185

Descrizione: Lysosomal acid lipase (LAL), with 378-amino acid protein( 43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI35-199)

Fornitore: ProSci Inc.

Codice articolo fornitore: 35-199

Codice articolo locale: PRSI35-199

Descrizione: Anti-Streptococcus Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

UOM: 1 * 1 mL

Promo

Codice catalogo: (PRSI35-204)

Fornitore: ProSci Inc.

Codice articolo fornitore: 35-204

Codice articolo locale: PRSI35-204

Descrizione: Anti-Helicobacter pylori Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 1 mL

Promo

Codice catalogo: (PRSI4401)

Fornitore: ProSci Inc.

Codice articolo fornitore: 4401

Codice articolo locale: PRSI4401

Descrizione: ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI35-141)

Fornitore: ProSci Inc.

Codice articolo fornitore: 35-141

Codice articolo locale: PRSI35-141

Descrizione: Anti-Cholera toxin Rabbit Polyclonal Antibody

UOM: 1 * 1 mL

Promo

Codice catalogo: (PRSI6095)

Fornitore: ProSci Inc.

Codice articolo fornitore: 6095

Codice articolo locale: PRSI6095

Descrizione: ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI92-261)

Fornitore: ProSci Inc.

Codice articolo fornitore: 92-261

Codice articolo locale: PRSI92-261

Descrizione: Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI91-651)

Fornitore: ProSci Inc.

Codice articolo fornitore: 91-651

Codice articolo locale: PRSI91-651

Descrizione: Mannoside Acetylglucosaminyltransferase 2 (MGAT2) is a single-pass type II membrane protein that contains the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain and a C-terminal catalytic domain. MGAT2 catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans. Defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI91-661)

Fornitore: ProSci Inc.

Codice articolo fornitore: 91-661

Codice articolo locale: PRSI91-661

Descrizione: 15-hydroxyprostaglandin dehydrogenase [NAD(+)], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI4893P)

Fornitore: ProSci Inc.

Codice articolo fornitore: 4893P

Codice articolo locale: PRSI4893P

Descrizione: DISP2 peptide is used for blocking the activity of DISP2 antibody.

UOM: 1 * 50 µG

Promo