Hai cercato: Bioss

Codice catalogo: (BOSSBS-0265R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-0265R-A488

Codice articolo locale: BOSSBS-0265R-A488

Descrizione: CKLFSF2 isoform 1

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13154R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-13154R-A488

Codice articolo locale: BOSSBS-13154R-A488

Descrizione: Adrenodoxin Reductase (ADX Reductase) is a mitochondrial flavoprotein that receives electrons from NADPH and thereby initiates the electron-transport chain serving mitochondrial cytochromes P450. ADX Reductase participates in cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-? hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney and sterol C-27 hydroxylation in the liver. Alternate splicing of ADX Reductase produces two isoforms. Human ADX Reductase maps to human chromosome 17q24-q25.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0520R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-0520R-A647

Codice articolo locale: BOSSBS-0520R-A647

Descrizione: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1859R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1859R-A750

Codice articolo locale: BOSSBS-1859R-A750

Descrizione: Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti-apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2083R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-2083R-A647

Codice articolo locale: BOSSBS-2083R-A647

Descrizione: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13306R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-13306R-A488

Codice articolo locale: BOSSBS-13306R-A488

Descrizione: intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90% similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13077R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-13077R-A555

Codice articolo locale: BOSSBS-13077R-A555

Descrizione: Equilibrative nucleoside transporters (ENTs) regulate many physiological processes and are widely distributed in mammals, plants, yeasts, insects, nematodes and protozoans. They enable facilitated diffusion of hydrophilic nucleosides, such as adenosine and nucleoside analogs, across cell membranes. ENTs are required for uptake of antiviral and anticancer nucleoside drugs and influence a variety of physiological processes, such as neurotransmission and platelet aggregation, by regulating the amount of adenoside available to cell surface receptors. Equilibrative nucleoside transporter 1 (ENT1), also designated solute carrier family 29 (nucleoside transporters), member 1, belongs to the SLC29A transporter family and is a mammalian ENT isoform. ENT1, along with ENT3, mediates the majority of influx and efflux of nucleosides across the plasma membrane.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0760R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-0760R-A350

Codice articolo locale: BOSSBS-0760R-A350

Descrizione: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2060R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-2060R-A555

Codice articolo locale: BOSSBS-2060R-A555

Descrizione: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5770R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5770R-A680

Codice articolo locale: BOSSBS-5770R-A680

Descrizione: FGF17 belongs to the heparin-binding growth factors family. It may be a signaling molecule in the induction and patterning of the embryonic brain and is preferentially expressed in the embryonic brain. There are two named isoforms.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13230R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13230R-A680

Codice articolo locale: BOSSBS-13230R-A680

Descrizione: Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. The carbohydrate moieties generated and covalently attached to cell surfaces are necessary to ensure a surface contour that satisfies physiological roles, which are reliant on adhesion molecules such as Selectins (1-3). Hematopoietic lineages rely on Fucosyltransferases to confer a surface carbohydrate phenotype, which mediates proper cell adhesion molecule recruitment and cell trafficking (4-6).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5539R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-5539R-A350

Codice articolo locale: BOSSBS-5539R-A350

Descrizione: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13290R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13290R-A647

Codice articolo locale: BOSSBS-13290R-A647

Descrizione: Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0626R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-0626R-A680

Codice articolo locale: BOSSBS-0626R-A680

Descrizione: Anti-ZNF268 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5671R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-5671R-A555

Codice articolo locale: BOSSBS-5671R-A555

Descrizione: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1333R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1333R-A750

Codice articolo locale: BOSSBS-1333R-A750

Descrizione: This gene encodes a protein expressed in tumor cells during apoptosis independent of the apoptosis-inducing stimuli. Prior to apoptosis induction, this gene product is distributed in both the nucleus and cytoplasm. Once apoptosis is induced, the level of this protein increases and by relocation from the cytoplasm, it accumulates in the nucleus. Although its exact function is not defined, this protein is thought to play an early and universal role in apoptosis.

UOM: 1 * 100 µl

Promo