Hai cercato: Bioss

Codice catalogo: (BOSSBS-11322R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-11322R-A555

Codice articolo locale: BOSSBS-11322R-A555

Descrizione: The gene encoding human Membralin, C19orf6, localizes to chromosome 19p13.3. It contains 11 exons, which encode at least two splice variants in human cancer. Membralin is a multi-pass membrane protein and exists either as a long or short form. The long form of Membralin comprises all 11 exons, while the short form contains all exons except exon 10. Expression of different Membralin isoforms depends on tissue type. The long form is expressed in ovarian and colorectal carcinomas, whereas the short form is expressed in breast or pancreatic carcinomas. Because Membralin expression in ovarian carcinomas is highest in serous carcinomas as compared to surface epithelium carcinomas, expression of Membralin may be useful as a novel tumor-associated marker in ovarian serous carcinomas.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13373R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13373R-A680

Codice articolo locale: BOSSBS-13373R-A680

Descrizione: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. GLI-4, also known as HKR4, is a 376 amino acid protein that localizes to the nucleus and contains seven C2H2-type zinc fingers. Belonging to the krueppel C2H2-type zinc-finger protein family, GLI-4 may function as a transcriptional regulator, effectively activating or repressing the transcription of target genes. The gene encoding GLI-4 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0123R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-0123R-A488

Codice articolo locale: BOSSBS-0123R-A488

Descrizione: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K >neuromedin-K >substance P.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5175R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5175R-A680

Codice articolo locale: BOSSBS-5175R-A680

Descrizione: Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1432R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-1432R-A555

Codice articolo locale: BOSSBS-1432R-A555

Descrizione: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0022R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-0022R-A680

Codice articolo locale: BOSSBS-0022R-A680

Descrizione: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localised in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10693R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-10693R-A680

Codice articolo locale: BOSSBS-10693R-A680

Descrizione: KIF15 belongs to the kinesin-like protein family and contains 1 kinesin-motor domain. KIF15 is the plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7818R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-7818R-A647

Codice articolo locale: BOSSBS-7818R-A647

Descrizione: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May bind and transfer a labile 4Fe-4S cluster to target apoproteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2928R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-2928R-A555

Codice articolo locale: BOSSBS-2928R-A555

Descrizione: The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5912R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5912R-A750

Codice articolo locale: BOSSBS-5912R-A750

Descrizione: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15116R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-15116R-A750

Codice articolo locale: BOSSBS-15116R-A750

Descrizione: C20orf74

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1894R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-1894R-A680

Codice articolo locale: BOSSBS-1894R-A680

Descrizione: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4894R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-4894R-A750

Codice articolo locale: BOSSBS-4894R-A750

Descrizione: Catalyses the transfer of sulfate to position 6 of galactose residues of keratan. It has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal galactose residues are sulfated. It also may function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. It participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Aggrecan is the major proteoglycan of human articular cartilage. The core protein is substituted by a number of keratan sulfate and chondroitin sulfate glycosaminoglycan chains. Whereas chondroitin sulfate is widely distributed throughout the body, keratan sulfate is primarily expressed in cartilage (joints, trachea, intervertebral discs) and cornea.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0264R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-0264R-A555

Codice articolo locale: BOSSBS-0264R-A555

Descrizione: Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1(muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1570R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1570R-A750

Codice articolo locale: BOSSBS-1570R-A750

Descrizione: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9553R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-9553R-A680

Codice articolo locale: BOSSBS-9553R-A680

Descrizione: The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unusual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The CXX1 gene product has been provisionally designated CXX1 pending further characterisation.

UOM: 1 * 100 µl

Promo