Hai cercato: Bioss

Codice catalogo: (BOSSBS-3950R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-3950R-A555

Codice articolo locale: BOSSBS-3950R-A555

Descrizione: The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0265R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-0265R-A488

Codice articolo locale: BOSSBS-0265R-A488

Descrizione: CKLFSF2 isoform 1

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5170R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5170R-A750

Codice articolo locale: BOSSBS-5170R-A750

Descrizione: ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9662R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-9662R-A750

Codice articolo locale: BOSSBS-9662R-A750

Descrizione: EFR3A is a plasma membrane protein that contains 821 amino acids and belongs to the EFR3 family. EFR3A is alternatively spliced creating three isoforms and is encoded by a gene that maps to human chromosome 8. Human chromosome 8 consists of nearly 146 million base pairs, encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukaemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11449R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-11449R-A350

Codice articolo locale: BOSSBS-11449R-A350

Descrizione: The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8189R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-8189R-A647

Codice articolo locale: BOSSBS-8189R-A647

Descrizione: CCDC18, also known as NY-SAR-41 or dJ717I23.1, is a 1,454 amino acid protein expressed as two isoforms and encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4957R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-4957R-A350

Codice articolo locale: BOSSBS-4957R-A350

Descrizione: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13597R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13597R-A647

Codice articolo locale: BOSSBS-13597R-A647

Descrizione: The homeobox protein, HESX1, which is also known as Rathke’s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism. Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBSM-1622M-A680)

Fornitore: Bioss

Codice articolo fornitore: BSM-1622M-A680

Codice articolo locale: BOSSBSM-1622M-A680

Descrizione: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0660R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-0660R-A680

Codice articolo locale: BOSSBS-0660R-A680

Descrizione: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0654R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-0654R-A350

Codice articolo locale: BOSSBS-0654R-A350

Descrizione: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13154R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-13154R-A488

Codice articolo locale: BOSSBS-13154R-A488

Descrizione: Adrenodoxin Reductase (ADX Reductase) is a mitochondrial flavoprotein that receives electrons from NADPH and thereby initiates the electron-transport chain serving mitochondrial cytochromes P450. ADX Reductase participates in cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-? hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney and sterol C-27 hydroxylation in the liver. Alternate splicing of ADX Reductase produces two isoforms. Human ADX Reductase maps to human chromosome 17q24-q25.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15519R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-15519R-A555

Codice articolo locale: BOSSBS-15519R-A555

Descrizione: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0520R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-0520R-A647

Codice articolo locale: BOSSBS-0520R-A647

Descrizione: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9874R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-9874R-A680

Codice articolo locale: BOSSBS-9874R-A680

Descrizione: Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. The common sialic acids of mammalian cells are N-acetyl-neuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc). Siglec-1 mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Siglec-7, highly expressed in monocytes and resident blood cells, but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Siglec-9 is closely homologous to Siglec-7; the gene encoding it maps to chromosome 19q13.41 in humans. It is highly expressed in peripheral blood leukocytes (but not eosinophils), liver, bone marrow, placenta and spleen. Siglec-8, a type I membrane protein, is selectively expressed on human eosinophils, basophils and mast cells, where it regulates their function and survival.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12335R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-12335R-A488

Codice articolo locale: BOSSBS-12335R-A488

Descrizione: The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3.

UOM: 1 * 100 µl

Promo