Hai cercato: Bioss

Codice catalogo: (BOSSBS-6539R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-6539R-A750

Codice articolo locale: BOSSBS-6539R-A750

Descrizione: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15031R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-15031R-HRP

Codice articolo locale: BOSSBS-15031R-HRP

Descrizione: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf159 gene product has been provisionally designated C1orf159 pending further characterization.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1497R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-1497R-CY3

Codice articolo locale: BOSSBS-1497R-CY3

Descrizione: The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1402R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-1402R-A488

Codice articolo locale: BOSSBS-1402R-A488

Descrizione: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5283R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5283R-A680

Codice articolo locale: BOSSBS-5283R-A680

Descrizione: The multiprotein exon junction complex (EJC) is deposited on mRNAs upstream of exonexon junctions as a consequence of pre-mRNA splicing. In mammalian cells, this complex serves as a key modulator of spliced mRNA metabolism. MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. The function of MLN51 in mammals remains elusive. Its fly homolog, named barentsz, as well as the proteins mago nashi and tsunagi have been shown to be required for proper oskar mRNA localization to the posterior pole of the oocyte. Magoh and Y14, the human homologs of mago nashi and tsunagi, are core components of the exon junction complex (EJC). The EJC is assembled on spliced mRNAs and plays important roles in post-splicing events including mRNA export, nonsense-mediated mRNA decay, and translation. Human MLN51 is an RNA-binding protein present in ribonucleo-protein complexes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5277R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5277R-A750

Codice articolo locale: BOSSBS-5277R-A750

Descrizione: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. cdk2 is a cell cycle protein closely related to Cdc2 (cdk1) that has proved useful as a marker of proliferation. cdk2 binds cyclin type A and E proteins and controls progression into S-phase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9812R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-9812R-A680

Codice articolo locale: BOSSBS-9812R-A680

Descrizione: GCF, also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of -Actin, EGFR and calcium-dependent protease (CANP) promoters. GCF contains multiple phosphoserine and phosphothreonine residues, and two GCF isoforms are produced due to alternative splicing events. GCF is considered a candidate for susceptibility to dyslexia (DYX3) as both genes reside in close proximity on human chromosome 2. Chromosome 2 is the second largest human chromosome and consists of 237 million bases, encodes over 1400 genes and makes up approximately 8% of the human genome.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5343R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5343R-A680

Codice articolo locale: BOSSBS-5343R-A680

Descrizione: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterised.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2016R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-2016R-A750

Codice articolo locale: BOSSBS-2016R-A750

Descrizione: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognise the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognise the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5826R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5826R-A680

Codice articolo locale: BOSSBS-5826R-A680

Descrizione: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2381R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-2381R-A750

Codice articolo locale: BOSSBS-2381R-A750

Descrizione: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5766R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5766R-A680

Codice articolo locale: BOSSBS-5766R-A680

Descrizione: RAB6C belongs to the small GTPase superfamily, Rab family.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1315R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1315R-A750

Codice articolo locale: BOSSBS-1315R-A750

Descrizione: Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon 4 regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilisation of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1525R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-1525R-HRP

Codice articolo locale: BOSSBS-1525R-HRP

Descrizione: Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1702R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-1702R-A680

Codice articolo locale: BOSSBS-1702R-A680

Descrizione: May catalyse alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0073R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-0073R-A680

Codice articolo locale: BOSSBS-0073R-A680

Descrizione: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.

UOM: 1 * 100 µl

Promo