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Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 555)

Codice catalogo: (BOSSBS-15482R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-15482R-A555
Codice articolo locale: BOSSBS-15482R-A555
Descrizione: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15482R

Anti-hHR23b Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-15482R)
Fornitore: Bioss
Codice articolo fornitore: BS-15482R
Codice articolo locale: BOSSBS-15482R
Descrizione: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl

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Image Unavailable-BOSSBS-6634R-A350

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-6634R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-6634R-A350
Codice articolo locale: BOSSBS-6634R-A350
Descrizione: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM: 1 * 100 µl
Image Unavailable-SPCMP1309-25GM

Potassio iodato ≥99.0% FCC

Codice catalogo: (SPCMP1309-25GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: P1309-25GM
Codice articolo locale: SPCMP1309-25GM
Descrizione: Potassium Iodate, FCC is used as a source for dietary iodine. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
UOM: 1 * 25 g
Image Unavailable-SPCMH1181-25GM

Hydroxyurea ≥97% USP

Fornitore: Spectrum Chemical
Descrizione: Hydroxyurea, USP is an antineoplastic drug used in myeloproliferative disorders. It has also been considered useful in treating painful attacks in sickle-cell disease and diseases like AIDS. The USP grade indicates it is graded suitable for personal care, cosmetic and pharmaceutical applications. All Spectrum Chemical USP grade products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMS1021-25GM

L(+)-Serina ≥98.5% FCC

Fornitore: Spectrum Chemical
Descrizione: L-Serine, FCC - The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMPE130-500GM

Petrolatum, giallo USP

Codice catalogo: (SPCMPE130-500GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: PE130-500GM
Codice articolo locale: SPCMPE130-500GM
Descrizione: Petrolatum, Yellow, USP is a carrier or vehicle excipient.
UOM: 1 * 500 g
Image Unavailable-SPCMS3437-100GM

Sucralose FCC

Fornitore: Spectrum Chemical
Descrizione: Sucralose, FCC is used as an artificial sweetener products that require a longer shelf life. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMSO193-500GM

Sodium pyruvate ≥99%, per analisi

Codice catalogo: (SPCMSO193-500GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: SO193-500GM
Codice articolo locale: SPCMSO193-500GM
Descrizione: Sodium Pyruvate, Reagent is most often added to the cell culture media as an extra source of energy. Sodium pyruvate also has a protective action against hydrogen peroxide. The Reagent grade denotes that this chemical is the highest quality commercially available and that the American Chemical Society has not officially set any specifications for this material. Spectrum Chemical manufactured Reagent grade products meet the toughest regulatory standards for quality and purity.
UOM: 1 * 500 g
Image Unavailable-SPCMP1344-2.5KG

Potassium iodide ≥99.0%, granular FCC

Fornitore: Spectrum Chemical
Descrizione: Potassium Iodide, Granular, FCC is used as a source for dietary iodine. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

Image Unavailable-SPCMPR130-500MLPL

(±)-1,2-Propandiolo ≥99.5% USP

Fornitore: Spectrum Chemical
Descrizione: Propylene Glycol, USP is used in pharmaceutical products as an excipient solvent in oral and topical drug products. All Spectrum Chemical USP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities

Image Unavailable-SPCMSO167-125GM

Sodium fluoride ≥98.5%, in polvere USP, Ph. Eur., BP

Codice catalogo: (SPCMSO167-125GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: SO167-125GM
Codice articolo locale: SPCMSO167-125GM
Descrizione: Sodium Fluoride, Powder, USP, EP, BP is used to prevent cavities making teeth stronger and more resistant to decay caused by acid and bacteria. Toothpaste being the preferred delivery method. All Spectrum Chemical USP, EP, BP products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
UOM: 1 * 125 g
Image Unavailable-SPCMC1888-2.5KG

Cetostearyl alcohol NF

Fornitore: Spectrum Chemical
Descrizione: Cetostearyl Alcohol, NF is used as a stabiliser and opacifying agent.

Image Unavailable-SPCMSO169-500GM

Sodium polyphosphate (Graham's salt), glassy FCC

Codice catalogo: (SPCMSO169-500GM)
Fornitore: Spectrum Chemical
Codice articolo fornitore: SO169-500GM
Codice articolo locale: SPCMSO169-500GM
Descrizione: Sodium Polyphosphates, Glassy, FCC is used as an acidity regulator, emulsifier and buffering agent, and as a sequestering agent. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
UOM: 1 * 500 g

Certificati


Image Unavailable-SPCMET110-500GM

Ethyl cellulose, 10 mPa.s NF

Fornitore: Spectrum Chemical
Descrizione: Ethylcellulose, 10 mPa.s, NF. 

Image Unavailable-SPCMPH120-1.5KGPL

Fenolo 99,0, crystals_fused USP

Fornitore: Spectrum Chemical
Descrizione: Fenolo 99,0, crystals_fused USP

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La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
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Puoi ordinare questo prodotto. Se necessario, ti contatteremo per richiedere licenza, autorizzazione o dichiarazione d'uso per procedere con la fornitura.
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Il prodotto marcato con questo simbolo non è più disponibile o vendibile fino ad esaurimento scorte. Alternative possono essere disponibili utilizzando il numero di catalogo VWR. Per maggiori informazioni può contattare il nostro customer service al 023320311 o inviando una email all'indirizzo ebusiness.italy@avantorsciences.com
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