Hai cercato: NBD+C6-Sphingomyelin

Codice catalogo: (BOSSBS-6318R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6318R-CY3

Codice articolo locale: BOSSBS-6318R-CY3

Descrizione: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.

UOM: 1 * 100 µl

Promo

Codice catalogo: (47100.)

Fornitore: Merck

Codice articolo fornitore: 47100

Codice articolo locale: SUPL47100

Descrizione: n-Paraffin Mix C5, C6, C7, C8, Supelco®, (varied conc.)

UOM: 1 * 1 pezzi

Promo

Codice catalogo: (BOSSBS-4216R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-HRP

Codice articolo locale: BOSSBS-4216R-HRP

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4216R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-CY5.5

Codice articolo locale: BOSSBS-4216R-CY5.5

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo

Fornitore: Apollo Scientific

Descrizione: 1-Iodoperfluoroalkanes C6-C12

Codice catalogo: (BOSSBS-13297R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-13297R-CY5

Codice articolo locale: BOSSBS-13297R-CY5

Descrizione: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13297R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-13297R-CY7

Codice articolo locale: BOSSBS-13297R-CY7

Descrizione: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

UOM: 1 * 100 µl

Promo

Fornitore: Oxford Nanopore Technologies

Descrizione: MinION™ - your personal, portable DNA and RNA sequencer.

New Product

Codice catalogo: (BOSSBS-13297R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13297R-A647

Codice articolo locale: BOSSBS-13297R-A647

Descrizione: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13297R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-13297R-A555

Codice articolo locale: BOSSBS-13297R-A555

Descrizione: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

UOM: 1 * 100 µl

Promo

Codice catalogo: (USBI042056-BIOTIN)

Fornitore: US Biological

Codice articolo fornitore: 042056-BIOTIN

Codice articolo locale: USBI042056-BIOTIN

Descrizione: Anti-SMPD3 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

Promo

Codice catalogo: (BOSSBS-6318R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-6318R-A350

Codice articolo locale: BOSSBS-6318R-A350

Descrizione: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6318R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-6318R-CY5.5

Codice articolo locale: BOSSBS-6318R-CY5.5

Descrizione: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6318R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-6318R-HRP

Codice articolo locale: BOSSBS-6318R-HRP

Descrizione: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4216R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-A350

Codice articolo locale: BOSSBS-4216R-A350

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13297R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13297R-A680

Codice articolo locale: BOSSBS-13297R-A680

Descrizione: Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

UOM: 1 * 100 µl

Promo