Hai cercato: N-Carbobenzoxy-L-tyrosine

Codice catalogo: (BOSSBS-6235R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-6235R-CY5

Codice articolo locale: BOSSBS-6235R-CY5

Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11645R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-11645R-A488

Codice articolo locale: BOSSBS-11645R-A488

Descrizione: Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo; catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8028R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-8028R-CY7

Codice articolo locale: BOSSBS-8028R-CY7

Descrizione: This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8028R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-8028R-CY5

Codice articolo locale: BOSSBS-8028R-CY5

Descrizione: This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (ABCAAB310901-100UL)

Fornitore: Abcam

Codice articolo fornitore: AB310901-100UL

Codice articolo locale: ABCAAB310901-100UL

Descrizione: Anti-Tyrosine Hydroxylase Rabbit Monoclonal Antibody [clone: EP1532Y] (PE)

UOM: 1 * 100 µl

Promo

Codice catalogo: (ABCAAB310825-100UL)

Fornitore: Abcam

Codice articolo fornitore: AB310825-100UL

Codice articolo locale: ABCAAB310825-100UL

Descrizione: Anti-Tyrosine Hydroxylase Rabbit Monoclonal Antibody [clone: EP1532Y] (APC)

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13155R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-13155R-FITC

Codice articolo locale: BOSSBS-13155R-FITC

Descrizione: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5325R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-5325R-CY5

Codice articolo locale: BOSSBS-5325R-CY5

Descrizione: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-CY5

Codice articolo locale: BOSSBS-13651R-CY5

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-A647

Codice articolo locale: BOSSBS-13651R-A647

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13651R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-13651R-A750

Codice articolo locale: BOSSBS-13651R-A750

Descrizione: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13155R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-13155R-HRP

Codice articolo locale: BOSSBS-13155R-HRP

Descrizione: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3089R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-3089R-CY5.5

Codice articolo locale: BOSSBS-3089R-CY5.5

Descrizione: The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL’s interaction with downstream targets of tyrosine kinases, such as PI 3K and Vav.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3089R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-3089R-CY7

Codice articolo locale: BOSSBS-3089R-CY7

Descrizione: The proto oncogene c CBL was initially identified as the cellular homologue of v CBL oncogene that induces pre B cell lymphomas and myeloid leukemias in mice. In more recent studies CBL has been shown to be a negative regulator of tyrosine kinase signaling. The ubiquitin ligase activity of CBL leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors. Targets of CBL include activated protein tyrosine kinases belonging to the Src and Syk/Zap 70 families. An additional mechanism to attenuate receptor signaling is thought to be achieved by CBL’s interaction with downstream targets of tyrosine kinases, such as PI 3K and Vav.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3463R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-3463R-CY3

Codice articolo locale: BOSSBS-3463R-CY3

Descrizione: Neuronal MarkerTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6235R)

Fornitore: Bioss

Codice articolo fornitore: BS-6235R

Codice articolo locale: BOSSBS-6235R

Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

UOM: 1 * 100 µl

Promo