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Hai cercato: N-Carbobenzoxy-L-tyrosine


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Codice catalogo: (BOSSBS-11645R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-11645R-CY7
Codice articolo locale: BOSSBS-11645R-CY7
Descrizione: Fish, a potential Src substrate, is a broadly expressed adaptor protein containing five SH3 domains and a phox homology (PX) domain (1). The Src family of protein tyrosine kinases act in signal transduction pathways (2-4). Src kinases vary in expression but are strongly regulated in vivo; catalytic activity is repressed by interacting with the SH3 domain (5-7). In Src-transformed fibroblasts and in normal cells treated with certain growth factors fish is tyrosine-phosphorylated (1). Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish, along with activation of Src (1). Fish is likely to be involved in tyrosine kinase signaling and may have a role in cytoskeletal changes (1).
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-6235R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-6235R-CY5
Codice articolo locale: BOSSBS-6235R-CY5
Descrizione: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
UOM: 1 * 100 µl


Codice catalogo: (USBIP9109-40R1)
Fornitore: US Biological
Codice articolo fornitore: P9109-40R1
Codice articolo locale: USBIP9109-40R1
Descrizione: Anti-Protein Tyrosine Phosphatase, Receptor Type R Mouse Monoclonal Antibody [clone: 6A6]
UOM: 1 * 100 µG


Codice catalogo: (BOSSBS-8028R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-8028R-CY7
Codice articolo locale: BOSSBS-8028R-CY7
Descrizione: This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-8028R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-8028R-CY5
Codice articolo locale: BOSSBS-8028R-CY5
Descrizione: This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-12942R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-12942R-FITC
Codice articolo locale: BOSSBS-12942R-FITC
Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-12941R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-12941R-A488
Codice articolo locale: BOSSBS-12941R-A488
Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-5624R)
Fornitore: Bioss
Codice articolo fornitore: BS-5624R
Codice articolo locale: BOSSBS-5624R
Descrizione: Src (also known as pp60src) is a non receptor Tyrosine Kinase involved in signal transduction in many biological systems and implicated in the development of human tumors. There are two critical phosphorylation sites of tyrosine on Src, tyrosine 418 and tyrosine 529 (referring to human Src sequence). The tyrosine 418 is located in the catalytic domain and is one of the autophosphorylation sites. Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus when tyrosine 529 is phosphorylated by Csk. This conformation blocks phosphorylation of tyrosine 418 at the catalytic domain, thereby preventing Src activation. When tyrosine 529 is dephosphorylated, tyrosine 418 can be maximally phosphorylated and Src becomes active. Src is a proto oncogene that may play a role in the regulation of embryonic development and cell growth. Mutations in this gene could be involved in the malignant progression of colon cancer. Immunogen: Synthetic peptide (Human) derived from the region of Src that contains tyrosine 529, based on the human sequence. The sequence is conserved in mouse (tyrosine 534), chicken (tyrosine 527) and frog (tyrosine 525).
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-3463R)
Fornitore: Bioss
Codice articolo fornitore: BS-3463R
Codice articolo locale: BOSSBS-3463R
Descrizione: Neuronal MarkerTyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into Parkinson's disease.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-13155R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-13155R-A680
Codice articolo locale: BOSSBS-13155R-A680
Descrizione: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-5326R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-5326R-A488
Codice articolo locale: BOSSBS-5326R-A488
Descrizione: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-12942R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-12942R-HRP
Codice articolo locale: BOSSBS-12942R-HRP
Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-10497R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-10497R-HRP
Codice articolo locale: BOSSBS-10497R-HRP
Descrizione: The phosphorylation of specific tyrosine residues has been shown to be a primary mechanism of signal transduction during normal mitogenesis, cell cycle progression and oncogenic transformation, its role in other areas such as differentiation and gap junction communication, is a matter of active and ongoing research. that specifically recognize phosphorylated tyrosine residues have proved to be invaluable to the study of tyrosine phosphorylated proteins and the biochemical pathways in which they function.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-12941R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-12941R-A647
Codice articolo locale: BOSSBS-12941R-A647
Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM: 1 * 100 µl


Codice catalogo: (BOSSBS-12941R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-12941R-A555
Codice articolo locale: BOSSBS-12941R-A555
Descrizione: All members of the Src gene family of tyrosine kinases are characterized by a carboxy terminal domain tyrosine which is highly phosphorylated in the inactive form of the enzyme and phosphorylated to a much lesser extent when the enzyme is active. In the case of Src p60, Y527 is this tyrosine; however, a mutant form of c-Src in which Y527 is replaced by phenylalanine is transforming and displays 5- to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src-related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as carboxy terminal regulatory sequences. Csk phosphorylates Src on Y527 and also downregulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy terminal regulatory sites.
UOM: 1 * 100 µl


Codice catalogo: (USBIP9109-40R2)
Fornitore: US Biological
Codice articolo fornitore: P9109-40R2
Codice articolo locale: USBIP9109-40R2
Descrizione: Anti-Protein Tyrosine Phosphatase, Receptor Type R Rabbit Polyclonal Antibody
UOM: 1 * 200 µl


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