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Image Unavailable-BOSSBS-13695R-CY7

Anti-PAG1 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-13695R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-13695R-CY7
Codice articolo locale: BOSSBS-13695R-CY7
Descrizione: The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13695R-CY5

Anti-PAG1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-13695R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-13695R-CY5
Codice articolo locale: BOSSBS-13695R-CY5
Descrizione: The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11352R-CY5

Anti-MAGI1/IRSP58 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-11352R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-11352R-CY5
Codice articolo locale: BOSSBS-11352R-CY5
Descrizione: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1970R-A350

Anti-LAMP1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-1970R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-A350
Codice articolo locale: BOSSBS-1970R-A350
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1970R-CY5

Anti-LAMP1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-1970R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-CY5
Codice articolo locale: BOSSBS-1970R-CY5
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1970R-A555

Anti-LAMP1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-1970R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-A555
Codice articolo locale: BOSSBS-1970R-A555
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1970R-CY3

Anti-LAMP1 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-1970R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-CY3
Codice articolo locale: BOSSBS-1970R-CY3
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1970R-CY5.5

Anti-LAMP1 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-1970R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-CY5.5
Codice articolo locale: BOSSBS-1970R-CY5.5
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
Image Unavailable-50026.

Rhod-590 tripotassium salt fluorescent indicator, for calcium determination

Codice catalogo: (50026.)
Fornitore: Biotium
Codice articolo fornitore: 50026
Codice articolo locale: BTIU50026
Descrizione: Membrane-impermeant calcium indicator that can be loaded into cells via microinjection or scrape loading.
UOM: 1 * 1 mg
Image Unavailable-BOSSBS-13695R-HRP

Anti-PAG1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-13695R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-13695R-HRP
Codice articolo locale: BOSSBS-13695R-HRP
Descrizione: The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk. Csk binding protein (Cbp), also designated phosphoprotein associated with glycosphingo-lipid-enriched microdomains (GEMs) or PAG, is a ubiquitously expressed transmembrane phosphoprotein that binds specifically to the SH2 domain of Csk. Cbp is involved in the membrane localization of Csk and in Csk-mediated inhibition of c-Src. In the plasma membrane, Cbp is exclusively localized in the GM1 ganglioside-enriched detergent-insoluble membrane domain, which is important in receptor-mediated signaling. Cbp is a component of the regulatory mechanism controlling the activity of membrane-associated Src-PTKs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9717R

Anti-Nidogen 2 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-9717R)
Fornitore: Bioss
Codice articolo fornitore: BS-9717R
Codice articolo locale: BOSSBS-9717R
Descrizione: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9717R-A750

Anti-Nidogen 2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-9717R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-9717R-A750
Codice articolo locale: BOSSBS-9717R-A750
Descrizione: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1824R-A680

Anti-Mitofilin/IMMT Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-1824R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-1824R-A680
Codice articolo locale: BOSSBS-1824R-A680
Descrizione: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4266R

Anti-TRIP10 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-4266R)
Fornitore: Bioss
Codice articolo fornitore: BS-4266R
Codice articolo locale: BOSSBS-4266R
Descrizione: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9665R-CY5

Anti-MREG Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-9665R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-9665R-CY5
Codice articolo locale: BOSSBS-9665R-CY5
Descrizione: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9665R-CY7

Anti-MREG Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-9665R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-9665R-CY7
Codice articolo locale: BOSSBS-9665R-CY7
Descrizione: Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity).
UOM: 1 * 100 µl
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