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Hydroxy-2-naphthalenylmethylphosphonic acid ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES

Descrizione: HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase (IC50 = 100µM); in rat adipocytes (IC50 = 10µM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor.

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Hydroxy-2-naphthalenylmethylphosphonic acid ≥95%, crystalline solid

Fornitore: Cayman Chemical

Descrizione: HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity.

HNMPA-(AM)3 ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES

Descrizione: HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

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