Hai cercato: Histamine+dihydrochloride

Codice catalogo: (BOSSBS-15186R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-15186R-A488

Codice articolo locale: BOSSBS-15186R-A488

Descrizione: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4870R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4870R-HRP

Codice articolo locale: BOSSBS-4870R-HRP

Descrizione: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7348R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-7348R-HRP

Codice articolo locale: BOSSBS-7348R-HRP

Descrizione: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7348R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-7348R-A555

Codice articolo locale: BOSSBS-7348R-A555

Descrizione: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

UOM: 1 * 100 µl

Promo

Fornitore: MP Biomedicals

Descrizione: Histamine Diphosphate Monohydrate is potent vasodilater.

Codice catalogo: (BOSSBS-0324R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-0324R-CY3

Codice articolo locale: BOSSBS-0324R-CY3

Descrizione: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (ENZOADI915063100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADI915063100

Codice articolo locale: ENZOADI915063100

Descrizione: Cyclic GMP (cGMP), which has been shown to be present at levels typically 10-100 fold lower than cAMP, is formed by the action of the enzyme guanylate cyclase on GTP. Some hormones, such as Acetylcholine, Insulin, and Oxytocin, as well as certain other chemicals like Serotonin and Histamine cause an increase in cGMP levels. Stimulators of guanylate cyclase such as the vasodilators nitroprusside, nitroglycerin, sodium nitrate, and nitric oxide (NO) also stimulate cGMP levels.

UOM: 1 * 100 µl

New Product Promo

Codice catalogo: (BOSSBS-4870R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-4870R-A555

Codice articolo locale: BOSSBS-4870R-A555

Descrizione: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.

UOM: 1 * 100 µl

Promo

Fornitore: ENZO LIFE SCIENCES

Descrizione: A novel, selective inhibitor of receptor-mediated calcium entry. It inhibits receptor-mediated calcium entry in stimulated platelets (IC50=8-12µM) neutrophils and endothelial cells at concentrations which do not affect internal Ca²⁺ release. Note, in some cells SK&F 96365 can activate a novel Ca²⁺ entry pathway. Blocks TRPC3 and TRPC6 activation. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

New Product

Codice catalogo: (BOSSBS-15186R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-15186R-A750

Codice articolo locale: BOSSBS-15186R-A750

Descrizione: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15186R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-15186R-HRP

Codice articolo locale: BOSSBS-15186R-HRP

Descrizione: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0324R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-0324R-A350

Codice articolo locale: BOSSBS-0324R-A350

Descrizione: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0324R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-0324R-A488

Codice articolo locale: BOSSBS-0324R-A488

Descrizione: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7348R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-7348R-A680

Codice articolo locale: BOSSBS-7348R-A680

Descrizione: As a major event in type allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcRIs on mast cells may inhibit the signal transduction from FcRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7348R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-7348R-A488

Codice articolo locale: BOSSBS-7348R-A488

Descrizione: As a major event in type Ⅰ allergic reaction,degranulation of mast cells is triggered by the interaction between specific IgEs and high affinity IgE receptors (FcεRIs) on mast cell membrane,and is followed by the release of a battery of inflammatory mediators,such as histamine,leukotrienes and arachidonic acid,and these inflammatory mediators in turn induce a series of allergic symptoms.Recently,Allergin-1 has been found to be an immunoglobulin-like receptor preferentially expressed on mast cells.The crosslinking of Allergin-1 to FcεRIs on mast cells may inhibit the signal transduction from FcεRIs to intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM),generate ITIM inhibitory signals,which then participate in the regulation of mast cell degranulation,and finally block the initiation of allergic inflammation.

UOM: 1 * 100 µl

Promo

Fornitore: Cayman Chemical

Descrizione: Nortriptyline is a tricyclic antidepressant that blocks norepinephrine and serotonin transporters (K_Ds = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (K_D = 1.1 µM). It also antagonises serotonin, histamine, muscarinic, and α-adrenergic receptors (K_is = 5.0, 8.5, 10, 40, and 60 nM for 5-HT_2A, 5-HT_2C, H₁, α₁, and M₁ receptors, respectively)<B>.</B>