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Product Image-EDVO316

Experimentation kits, in search of the cholesterol gene

Codice catalogo: (EDVO316)
Fornitore: EDVOTEK
Codice articolo fornitore: 316
Codice articolo locale: EDVO316
Descrizione: Coronary heart disease and stroke are major causes of death in the Western world. Elevated blood cholesterol levels are a serious risk factor in both conditions. The genetic disease familial hypersholesterolemia (FH) causes an increase in blood levels of the bad form of cholesterol, low density lipoprotein (LDL). In untreated patients with the mutant FH gene, the condition can cause premature death. This experiment introduces the colorimetric enzymatic reaction which is the basis of the clinical cholesterol test. In addition, using agarose gel electrophoresis, students can analyse a simulated genetic screening for a disease.
UOM: 1 * 1 KIT
Image Unavailable-ICNA0210138205

Colesterolo ≥99%, white powder

Fornitore: MP Biomedicals
Descrizione: Cholesterol is a component used for the preparation and study of artificial model membranes. One example is a study of valinomycin induced changes in membrane potentials of red blood cell and phospholipid (phosphatidylcholine from egg yolk plus cholesterol) vesicle suspensions. Positively charged cyanine dyes were used that fluorimetrically respond to the change in potential. Cholesterol is suitable for use in liposome preparations. It is standard for clinical work.

Image Unavailable-ICNA0215948082

Digitonin, white powder

Fornitore: MP Biomedicals
Descrizione: Digitonin is a mild nonionic detergent. It permeabilizes plasma membranes of eukaryotic cells by complexing with membrane cholesterol and other unconjugated β-hydroxysterols.

Product Image-22637.415

Carbone attivo, in polvere, GPR RECTAPUR®

Fornitore: VWR Chemicals
Descrizione: Carbone attivo, in polvere, GPR RECTAPUR®

MSDS Certificati

Image Unavailable-BNUM0236-50

Anti-Progesterone Mouse Monoclonal Antibody (Purified, BSA-free) [clone: 6-5E-3F]

Codice catalogo: (BNUM0236-50)
Fornitore: Biotium
Codice articolo fornitore: BNUM0236-50
Codice articolo locale: BTIUBNUM0236-50
Descrizione: This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrinological investigations in women. This MAb may prove useful in identification of ovarian tumors.
UOM: 1 * 50 µl
Image Unavailable-BNC400236-500

Anti-Progesterone Mouse Monoclonal Antibody (CF640R) [clone: 6-5E-3F]

Fornitore: Biotium
Descrizione: This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrinological investigations in women. This MAb may prove useful in identification of ovarian tumors.

Image Unavailable-BNC471218-500

Anti-CELA3B Mouse Monoclonal Antibody (CF647) [clone: CELA3B/1218]

Fornitore: Biotium
Descrizione: This MAb recognizes a protein of ~17 kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Image Unavailable-BNC881218-100

Anti-CELA3B Mouse Monoclonal Antibody (CF488A) [clone: CELA3B/1218]

Fornitore: Biotium
Descrizione: This MAb recognizes a protein of ~17 kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B). Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

Image Unavailable-BOSSBS-7411R-CY3

Anti-Pantophysin Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-7411R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-7411R-CY3
Codice articolo locale: BOSSBS-7411R-CY3
Descrizione: The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. Pantophysin, also known as SYPL1 (synaptophysin-like protein 1) or H-SP1, is a 259 amino acid multi-pass membrane protein that localizes to melanosomes and vesicles, as well as to the cytoplasm, and contains one MARVEL domain. Expressed as multiple alternatively spliced isoforms, pantophysin is present in tissues throughout the body where it may play a role in vesicle trafficking and protein transport. The gene encoding pantophysin maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
UOM: 1 * 100 µl
Product Image-84147.362

Carbone attivo, GPR RECTAPUR® per adsorbimento gas

Fornitore: VWR Chemicals
Descrizione: Carbone attivo, GPR RECTAPUR® per adsorbimento gas

MSDS Certificati

Product Image-87126.230

Carbone attivo, in polvere, AnalaR NORMAPUR® per analisi

Codice catalogo: (87126.230)
Fornitore: VWR Chemicals
Codice articolo locale: VWRC87126.230
Descrizione: Carbone attivo, in polvere, AnalaR NORMAPUR® per analisi
UOM: 1 * 250 g

MSDS Certificati


Image Unavailable-75335-1L

Sodium bicarbonate : Sodium carbonate (100 mM : 100 mM) eluent concentrate for IC (20x) for Metrosep A Supp 10, Supelco®

Codice catalogo: (75335-1L)
Fornitore: Merck
Codice articolo fornitore: 75335-1L
Codice articolo locale: SUPL75335-1L
Descrizione: Sodium bicarbonate : Sodium carbonate (100 mM : 100 mM) eluent concentrate for IC (20x) for Metrosep A Supp 10, Supelco®
UOM: 1 * 1 L

Certificati


Image Unavailable-PRSI92-268

Human recombinant Apolipoprotein A-I (from E. coli)

Codice catalogo: (PRSI92-268)
Fornitore: ProSci Inc.
Codice articolo fornitore: 92-268
Codice articolo locale: PRSI92-268
Descrizione: Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including Tangier disease (TGD), systemic non-neuropathic amyloidosis, premature coronary artery disease, hepatosplenomegaly and progressive muscle wasting and weakness. In addition, ApoA-I is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.
UOM: 1 * 50 µG
Image Unavailable-BOSSBS-1383R-HRP

Anti-CD13/APN/ANPEN Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Codice catalogo: (BOSSBS-1383R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-1383R-HRP
Codice articolo locale: BOSSBS-1383R-HRP
Descrizione: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
UOM: 1 * 100 µl
Image Unavailable-BNC880237-100

Anti-Progesterone Mouse Monoclonal Antibody (CF488A) [clone: 6-5E-10B]

Fornitore: Biotium
Descrizione: This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5% and 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrinological investigations in women. This MAb may prove useful in identification of ovarian tumors.

Image Unavailable-BNC940236-500

Anti-Progesterone Mouse Monoclonal Antibody (CF594) [clone: 6-5E-3F]

Fornitore: Biotium
Descrizione: This MAb is specific for progesterone. It exhibits minimal cross reactivity with related compounds in ELISA. It reacts with Progesterone-11a-HMS-BSA: 100%; 5-beta-Pregnane-3,20-dione: 48%; 5-alpha-Pregnane-3,20-dione: 26.4%; 17-alpha-Hydroxyprogesterone: 2.5%; 20-alpha-Hydroxyprogesterone: 0.04%. Progesterone is a steroid hormone synthesized from the cholesterol derivative, pregnenolone, in the cortex of the adrenal gland. Progesterone is secreted by the corpus luteum and acts to prepare the endometrium for the implantation of a fertilized egg. During pregnancy, it is secreted by the placenta to prevent spontaneous abortion and to stimulate the development of mammary tissue to produce milk. Thus, progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Luteinized theca cells of normal ovary secrete progesterone. The determination of progesterone concentrations in the body fluids is of great value for endocrinological investigations in women. This MAb may prove useful in identification of ovarian tumors.

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La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
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