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Image Unavailable-BOSSBS-12498R-CY5

Anti-APOL1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-12498R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-12498R-CY5
Codice articolo locale: BOSSBS-12498R-CY5
Descrizione: Apolipoproteins are protein components of plasma lipoproteins (1). The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI, which are associated with large high density type lipoproteins (HDL) (2,3). The human apoL family maps to chromosome 22q12.1-13.1 within a 127,000-bp region (4). ApoL has been characterized as a pancreas specific, 383-amino acid protein that contains a 12-amino acid secretory signal peptide (4). The apoL genes have TATA-less promoters and contain putative sterol regulatory elements, suggesting that transcription of these genes may be coordinated with that of the low density lipoprotein receptor and genes in pathways involving the synthesis of triglycerides and cholesterol (3). ApoL homologs can undergo 10 fold changes in expression during atherosclerotic changes in vascular endothelial cells, which includes the inflammatory reaction of atherosclerotic lesions (5).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2443R-A555

Anti-CYP21A2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-2443R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-2443R-A555
Codice articolo locale: BOSSBS-2443R-A555
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
UOM: 1 * 100 µl
Image Unavailable-TCIAC0043-25G

Diphenyl carbonate ≥99.0% (by GC)

Fornitore: TCI
Descrizione: Diphenyl carbonate ≥99.0% (by GC)

Image Unavailable-38302-2.5L

Sodium carbonate : Sodium hydroxide concentrato (150 mM : 15 mM) in water IC eluent concentrate (20x) for Metrosep A Supp 16, Supelco®

Fornitore: Merck
Descrizione: Sodium carbonate : Sodium hydroxide concentrato (150 mM : 15 mM) in water IC eluent concentrate (20x) for Metrosep A Supp 16, Supelco®

Image Unavailable-BOSSBS-3936R-A647

Anti-SLC27A2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-3936R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-3936R-A647
Codice articolo locale: BOSSBS-3936R-A647
Descrizione: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9036R-CY5.5

Anti-PDZK1 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-9036R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-9036R-CY5.5
Codice articolo locale: BOSSBS-9036R-CY5.5
Descrizione: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9036R-A647

Anti-PDZK1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-9036R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-9036R-A647
Codice articolo locale: BOSSBS-9036R-A647
Descrizione: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9036R-A555

Anti-PDZK1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-9036R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-9036R-A555
Codice articolo locale: BOSSBS-9036R-A555
Descrizione: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13153R-CY5

Anti-FDPS Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-13153R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-13153R-CY5
Codice articolo locale: BOSSBS-13153R-CY5
Descrizione: FDPS is a 419 amino acid enzyme belonging to the FPP/GGPP synthetase family. Localized to cytoplasm and peroxisome, FDPS expression is regulated by phorbol esters and polyunsaturated fatty acids. FDPS assists in cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones in the isoprenoid pathway.FDPS catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FDPS is inactivated by interferon-induced RSAD2, which may result in the disruption of lipid rafts at the plasma membrane. Existing as a homodimer, FDPS may have anti-viral effects when inactivated by RSAD2. Reduced activity of FDPS in liver may partly be the cause of Zellweger syndrome and neonatal adrenoleukodystrophy, both of which are known to be peroxisomal deficiency diseases.
UOM: 1 * 100 µl
Product Image-EDVO316

Experimentation kits, in search of the cholesterol gene

Codice catalogo: (EDVO316)
Fornitore: EDVOTEK
Codice articolo fornitore: 316
Codice articolo locale: EDVO316
Descrizione: Coronary heart disease and stroke are major causes of death in the Western world. Elevated blood cholesterol levels are a serious risk factor in both conditions. The genetic disease familial hypersholesterolemia (FH) causes an increase in blood levels of the bad form of cholesterol, low density lipoprotein (LDL). In untreated patients with the mutant FH gene, the condition can cause premature death. This experiment introduces the colorimetric enzymatic reaction which is the basis of the clinical cholesterol test. In addition, using agarose gel electrophoresis, students can analyse a simulated genetic screening for a disease.
UOM: 1 * 1 KIT
Image Unavailable-SPCMCH135-25GM

Colesterolo NF

Fornitore: Spectrum Chemical
Descrizione: BSE/TSE statement (available upon request) Allergen statement (available upon request)

Product Image-MICS69069-SP250

HPLC columns, Cogent UDC-Cholesterol™

Fornitore: MICROSOLV
Descrizione: The many advanced features of the this column produces a very stable, efficient and unique HPLC column with unique selectivity for steroids and other compounds.

Image Unavailable-BOSSBS-13153R-A680

Anti-FDPS Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-13153R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-13153R-A680
Codice articolo locale: BOSSBS-13153R-A680
Descrizione: FDPS is a 419 amino acid enzyme belonging to the FPP/GGPP synthetase family. Localized to cytoplasm and peroxisome, FDPS expression is regulated by phorbol esters and polyunsaturated fatty acids. FDPS assists in cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones in the isoprenoid pathway.FDPS catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FDPS is inactivated by interferon-induced RSAD2, which may result in the disruption of lipid rafts at the plasma membrane. Existing as a homodimer, FDPS may have anti-viral effects when inactivated by RSAD2. Reduced activity of FDPS in liver may partly be the cause of Zellweger syndrome and neonatal adrenoleukodystrophy, both of which are known to be peroxisomal deficiency diseases.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3901R-A680

Anti-Cubilin Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-3901R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-3901R-A680
Codice articolo locale: BOSSBS-3901R-A680
Descrizione: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-foetal interface.
UOM: 1 * 100 µl
Product Image-PRSI96-561

Human recombinant He1 (from HEK293 cells)

Codice catalogo: (PRSI96-561)
Fornitore: ProSci Inc.
Codice articolo fornitore: 96-561
Codice articolo locale: PRSI96-561
Descrizione: Niemann-Pick disease type C2 protein (NPC2) is also known as epididymal secretory protein E1 and human epididymis-specific protein 1 (HE1). NPC2 is a intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. Also,NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Furthermore,the secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-3026R-CY5

Anti-PRKAB1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-3026R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-3026R-CY5
Codice articolo locale: BOSSBS-3026R-CY5
Descrizione: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
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