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Codice catalogo: (BOSSBS-11083R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-11083R-A750

Codice articolo locale: BOSSBS-11083R-A750

Descrizione: Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells. Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, as well as an ER/SR membrane spanning hydrophobic C-terminal segment. The three subtypes in this family are Junctophilin-1, -2 and -3. Junctophilin-1 is predominantly expressed in skeletal muscle, but is also expressed at low levels in heart. Junctophilin-2 is expressed in heart and skeletal muscle. Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients. Junctophilin-3 is expressed in brain. The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder.

UOM: 1 * 100 µl

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Fornitore: Thermo Fisher Scientific

Descrizione: Queste colonne offrono una ritenzione ottimale per composti non polari e separazione di un'ampia gamma di analiti. Basate su una tecnologia Core Enhanced, garantiscono separazioni rapide ad alta risoluzione senza contropressioni elevate necessarie per le particelle inferiori a 2 µm.

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Codice catalogo: (BOSSBS-4056R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-4056R-A750

Codice articolo locale: BOSSBS-4056R-A750

Descrizione: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

UOM: 1 * 100 µl

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Codice catalogo: (554-2329)

Fornitore: Thermo Fisher Scientific

Codice articolo fornitore: 27726-102130

Codice articolo locale: HYPE27726-102130

Descrizione: These columns offer a unique HILIC selectivity and low ion exchange activity. Based on Core Enhanced Technology, they provide fast, high resolution separations without the elevated back pressures required by sub-2 µm particles.

UOM: 1 * 1 pezzi

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Fornitore: Thermo Fisher Scientific

Descrizione: Contains a C4 linker which allows for superior alignment of the phenyl ring with aromatic molecules. Get excellent retention and unique selectivity for aromatic and moderately polar analytes with Thermo Scientific™ Hypersil GOLD™ Phenyl reversed phase HPLC columns.

Codice catalogo: (BOSSBS-4056R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-4056R-A680

Codice articolo locale: BOSSBS-4056R-A680

Descrizione: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

UOM: 1 * 100 µl

Promo

Fornitore: MP Biomedicals

Descrizione: Urea is the principal end product of nitrogen metabolism in most mammals, formed by the enzymatic reactions of the Kreb's cycle.

Codice catalogo: (BOSSBS-3574R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-3574R-A680

Codice articolo locale: BOSSBS-3574R-A680

Descrizione: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3574R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-3574R-A750

Codice articolo locale: BOSSBS-3574R-A750

Descrizione: Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (PRSI2051)

Fornitore: ProSci Inc.

Codice articolo fornitore: 2051

Codice articolo locale: PRSI2051

Descrizione: ADAM10 Antibody: Proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha ) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha , notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-alpha , notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

UOM: 1 * 100 µG

Promo

Codice catalogo: (MLDVIXHCSAIADV)

Fornitore: Molecular Devices

Codice articolo fornitore: IXHCSAIADV

Codice articolo locale: MLDVIXHCSAIADV

Descrizione: <p>The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the data you need with ease.</p>

UOM: 1 * 1 pezzi

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