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NucSpot® nuclear stain

Fornitore: Biotium
Descrizione: Cell membrane-impermeant, nuclear-specific counterstains. Suitable for fixed cells or staining dead cells in live cultures.

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Anti-MAGI1/IRSP58 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-11352R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-11352R-A350
Codice articolo locale: BOSSBS-11352R-A350
Descrizione: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
UOM: 1 * 100 µl
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Anti-LAMP-1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-1970R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-A750
Codice articolo locale: BOSSBS-1970R-A750
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localisation of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
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Anti-Pseudomonas Outer membrane porin F Rabbit Monoclonal Antibody [clone: EPR28629-91]

Fornitore: Abcam
Descrizione: Anti-Pseudomonas Outer membrane porin F Rabbit Monoclonal Antibody [clone: EPR28629-91]

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Image Unavailable-BOSSBS-13110R-A350

Anti-ETFDH Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-13110R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-13110R-A350
Codice articolo locale: BOSSBS-13110R-A350
Descrizione: Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
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Anti-ETFDH Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-13110R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-13110R-CY5
Codice articolo locale: BOSSBS-13110R-CY5
Descrizione: Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2945R-A647

Anti-SNX1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-2945R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-2945R-A647
Codice articolo locale: BOSSBS-2945R-A647
Descrizione: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).
UOM: 1 * 100 µl
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Anti-LAPTM4A Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-9562R)
Fornitore: Bioss
Codice articolo fornitore: BS-9562R
Codice articolo locale: BOSSBS-9562R
Descrizione: Lysosomal-associated transmembrane protein 4A (LAPTM4A), also known as Golgi 4-transmembrane spanning transporter MTP, is a 233 amino acid protein belonging to the LAPTM5/LAPTM5 transporter family. LAPTM4A is subcellularly localized to the intracytoplasmic membrane and has the potential to reside in intracellular membrane-bound compartments. LAPTM4A is thought to function as a transporter of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of intracellular compartments. LAPTM4A is predicted to have four transmembrane domains, with the C-terminal domain being required for retention of the protein within intracellular membranes.
UOM: 1 * 100 µl
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Anti-Collagen 7 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-1558R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-1558R-A350
Codice articolo locale: BOSSBS-1558R-A350
Descrizione: Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
UOM: 1 * 100 µl
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Cartridge filters, Impact® 2 V2

Fornitore: ENTEGRIS
Descrizione: Superior retention performance for ultra-clean, point-of-use filtration of photoresist and photochemical solvents.

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Anti-USO1 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-4258R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-4258R-CY5
Codice articolo locale: BOSSBS-4258R-CY5
Descrizione: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity).
UOM: 1 * 100 µl
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Anti-LAMP-1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-1970R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-1970R-A680
Codice articolo locale: BOSSBS-1970R-A680
Descrizione: Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localisation of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM: 1 * 100 µl
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Anti-NID2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-9717R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-9717R-A350
Codice articolo locale: BOSSBS-9717R-A350
Descrizione: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9717R-A488

Anti-NID2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-9717R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-9717R-A488
Codice articolo locale: BOSSBS-9717R-A488
Descrizione: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9717R-CY5

Anti-NID2 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-9717R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-9717R-CY5
Codice articolo locale: BOSSBS-9717R-CY5
Descrizione: Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1402R-A488

Anti-SREBP-1/2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-1402R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-1402R-A488
Codice articolo locale: BOSSBS-1402R-A488
Descrizione: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
UOM: 1 * 100 µl
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