Hai cercato: 1-Methyl-N-carbobenzoxy-L-glutamate

Codice catalogo: (BOSSBS-13263R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13263R-A680

Codice articolo locale: BOSSBS-13263R-A680

Descrizione: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3301R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-3301R-A750

Codice articolo locale: BOSSBS-3301R-A750

Descrizione: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2139R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-2139R-FITC

Codice articolo locale: BOSSBS-2139R-FITC

Descrizione: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

UOM: 1 * 100 µl

Promo

Fornitore: TCI

Descrizione: (S)-2-(((Benzyloxy)carbonyl)amino)pentanedioic acid ≥98.0% (by HPLC, titration analysis)

Codice catalogo: (BOSSBS-12032R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-12032R-CY3

Codice articolo locale: BOSSBS-12032R-CY3

Descrizione: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1803R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-1803R-CY3

Codice articolo locale: BOSSBS-1803R-CY3

Descrizione: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12032R)

Fornitore: Bioss

Codice articolo fornitore: BS-12032R

Codice articolo locale: BOSSBS-12032R

Descrizione: Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10341R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-10341R-A680

Codice articolo locale: BOSSBS-10341R-A680

Descrizione: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyses the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2139R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-2139R-CY5

Codice articolo locale: BOSSBS-2139R-CY5

Descrizione: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10341R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-10341R-CY7

Codice articolo locale: BOSSBS-10341R-CY7

Descrizione: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10341R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-10341R-A555

Codice articolo locale: BOSSBS-10341R-A555

Descrizione: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10341R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-10341R-A488

Codice articolo locale: BOSSBS-10341R-A488

Descrizione: This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2139R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-2139R-HRP

Codice articolo locale: BOSSBS-2139R-HRP

Descrizione: L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13263R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-13263R-A750

Codice articolo locale: BOSSBS-13263R-A750

Descrizione: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13390R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13390R-A680

Codice articolo locale: BOSSBS-13390R-A680

Descrizione: GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8403R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-8403R-CY5

Codice articolo locale: BOSSBS-8403R-CY5

Descrizione: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Synaptic and extrasynaptic NMDA receptors have been shown to have opposite effects on neuronal survival, CREB function and gene regulation. Gcom1 (GRINL1A complex locus protein 1), also known as GUP (GRINL1A upstream protein) and Gcom (GRINL1A combined protein), is a 466 amino acid protein that is a component of the GRINL1A complex transcription unit, which is thought to be involved in the modulation of glutamatergic neurotransmission through interaction with the NR1 subunit of the NMDA receptor. Gcom1 is expressed in small intestine, lung, liver, heart, skeletal muscle, testis and prostate and also colocalizes with NR1 in cortical and hippocampal neurons. There are eleven isoforms of Gcom1 that are produced as a result of alternative splicing events.

UOM: 1 * 100 µl

Promo