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Leak-proof, solid stoppers seal bottles, flasks, vials, and even tubing to prevent liquids and gases escaping. Multi-hole styles provide the limited flow stability conditions desired in order to prevent air bubble build up. With a slightly tapered design, different diameter sized stoppers are inserted in labware for a snug fit that still allows easy removal. The closures are manufactured in different materials for accurate resistance to harsh contents and can maintain vacuum atmosphere.