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Descrizione: Leukemia inhibitory factor (LIF) is a member of the interleukin 6 (IL-6) family that is made by a variety of adult and embryonic tissues. LIF signals through the glycoprotein 130 (gp130)/LIF receptor (LIFR) heterodimer to activate STAT3 and MAPK signaling. LIF functions during hematopoietic differentiation, neuronal cell differentiation, kidney development, and inflammatory processes. Mouse LIF promotes mouse embryonic stem (ES) cell self-renewal and pluripotency in long-term cell culture systems, similar to the functional activity of FGF-basic in human ES cell culture systems.
Codice catalogo: SHBT200-33-20UG
UOM: 1 * 20 µG
Codice articolo fornitore: 200-33-20UG
Codice articolo locale: SHBT200-33-20UG
Fornitore: Shenandoah Biotechnology


Descrizione: Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin.  Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-β) family members, such as activin, bone morphogenetic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-β1.
Codice catalogo: SHBT200-20AF-100UG
UOM: 1 * 100 µG
Codice articolo fornitore: 200-20AF-100UG
Codice articolo locale: SHBT200-20AF-100UG
Fornitore: Shenandoah Biotechnology


Descrizione: Interleukin 7 (IL-7) is a hematopoietic cytokine that is an important regulator of B and T cell development. IL-7 is secreted by bone marrow and thymic stromal cells, dendritic cells, intestinal epithelial cells, hepatocytes, and keratinocytes. IL-7 signals through the interleukin 7 receptor (IL-7R) to promote the differentiation of hematopoietic stem cells into T cells, B cells, and natural killer cells. IL-7 is also a regulator of intestinal mucosal lymphocyte proliferation. Human and mouse IL-7 show species cross-reactivity.
Codice catalogo: SHBT200-03-100UG
UOM: 1 * 100 µG
Codice articolo fornitore: 200-03-100UG
Codice articolo locale: SHBT200-03-100UG
Fornitore: Shenandoah Biotechnology


Descrizione: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Codice catalogo: SHBT100-12AF-1MG
UOM: 1 * 1 mg
Codice articolo fornitore: 100-12AF-1MG
Codice articolo locale: SHBT100-12AF-1MG
Fornitore: Shenandoah Biotechnology


Descrizione: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF promotes immune system development and regulates neutrophil function during infection.
Codice catalogo: SHBT300-03-100UG
UOM: 1 * 100 µG
Codice articolo fornitore: 300-03-100UG
Codice articolo locale: SHBT300-03-100UG
Fornitore: Shenandoah Biotechnology


Descrizione: CD40 ligand (CD40L) or CD154 is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells.
Codice catalogo: SHBT100-25AF-50UG
UOM: 1 * 50 µG
Codice articolo fornitore: 100-25AF-50UG
Codice articolo locale: SHBT100-25AF-50UG
Fornitore: Shenandoah Biotechnology


Descrizione: Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. The application of FGF-basic is a critical component for human embryonic stem cell culture systems and is necessary for maintaining human embryonic stem cells in an undifferentiated state.
Codice catalogo: SHBT200-12-500UG
UOM: 1 * 500 µG
Codice articolo fornitore: 200-12-500UG
Codice articolo locale: SHBT200-12-500UG
Fornitore: Shenandoah Biotechnology


Descrizione: Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).
Codice catalogo: SHBT200-06AF-1MG
UOM: 1 * 1 mg
Codice articolo fornitore: 200-06AF-1MG
Codice articolo locale: SHBT200-06AF-1MG
Fornitore: Shenandoah Biotechnology

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Descrizione: Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation. IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth. IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation.
Codice catalogo: SHBT200-86-10UG
UOM: 1 * 10 µG
Codice articolo fornitore: 200-86-10UG
Codice articolo locale: SHBT200-86-10UG
Fornitore: Shenandoah Biotechnology


Descrizione: Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases. Therefore, IL-15 may serve as an effective therapeutic target, due to the beneficial outcomes of IL-15 neutralisation in models of psoriasis and diabetes. Human IL-15 shows activity on mouse cells.
Codice catalogo: SHBT100-86-10UG
UOM: 1 * 10 µG
Codice articolo fornitore: 100-86-10UG
Codice articolo locale: SHBT100-86-10UG
Fornitore: Shenandoah Biotechnology


Descrizione: Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. FGF-basic is a critical component for embryonic stem cell culture systems and is necessary for maintaining cells in an undifferentiated state. Recombinant FGF-basic 154 is the full length FGF-basic protein encoded by the human FGF-2 gene. FGF-basic 154 is the most popular tissue culture product at Shenandoah Biotechnology, Inc. There are no detectable differences in biological activity between FGF-basic 154 and the truncated FGF-basic 147 proteins.
Codice catalogo: SHBT100-146-100UG
UOM: 1 * 100 µG
Codice articolo fornitore: 100-146-100UG
Codice articolo locale: SHBT100-146-100UG
Fornitore: Shenandoah Biotechnology


Descrizione: Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.
Codice catalogo: SHBT100-200AF-100U
UOM: 1 * 100 µG
Codice articolo fornitore: 100-200AF-100U
Codice articolo locale: SHBT100-200AF-100U
Fornitore: Shenandoah Biotechnology


Descrizione: Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis.CNTF also plays an important protective role during nervous system injury.
Codice catalogo: SHBT100-59-500UG
UOM: 1 * 500 µG
Codice articolo fornitore: 100-59-500UG
Codice articolo locale: SHBT100-59-500UG
Fornitore: Shenandoah Biotechnology


Descrizione: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is hematopoietic growth factor produced by endothelial cells, monocytes, fibroblasts, and T cells. GM-CSF stimulates the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells. GM-CSF promotes immune system development and regulates neutrophil function during infection. Human and mouse GM-CSF show no cross-reactivity.
Codice catalogo: SHBT200-15-500UG
UOM: 1 * 500 µG
Codice articolo fornitore: 200-15-500UG
Codice articolo locale: SHBT200-15-500UG
Fornitore: Shenandoah Biotechnology


Descrizione: Prolactin is a hormone that is produced and secreted by the pituitary gland. Prolactin acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. Prolactin signal transduction occurs via JAK kinase signaling pathways. The primary function of prolactin is to regulate lactation, but prolactin also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.
Codice catalogo: SHBT300-11AF-500UG
UOM: 1 * 500 µG
Codice articolo fornitore: 300-11AF-500UG
Codice articolo locale: SHBT300-11AF-500UG
Fornitore: Shenandoah Biotechnology


Descrizione: Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin βA chains. Cleavage of the N-terminal propeptide renders the Activin protein biologically active. Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.
Codice catalogo: SHBT800-01AF-100UG
UOM: 1 * 100 µG
Codice articolo fornitore: 800-01AF-100UG
Codice articolo locale: SHBT800-01AF-100UG
Fornitore: Shenandoah Biotechnology


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