Hai cercato: ENZO LIFE SCIENCES

Codice catalogo: (ENZOADIKAPMA010E)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADIKAPMA010E

Codice articolo locale: ENZOADIKAPMA010E

Descrizione: MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804034C050)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804034C050

Codice articolo locale: ENZOALX804034C050

Descrizione: Anti-Enhancer for Ligands Monoclonal Antibody

UOM: 1 * 50 µG

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Codice catalogo: (ENZOALX803335C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX803335C100

Codice articolo locale: ENZOALX803335C100

Descrizione: All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA). c-IAP1 has been shown to inhibit specific caspases.

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804015C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804015C100

Codice articolo locale: ENZOALX804015C100

Descrizione: The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804077R100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804077R100

Codice articolo locale: ENZOALX804077R100

Descrizione: Host: Mouse, Isotype: IgG3

UOM: 1 * 100 µl

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Codice catalogo: (ENZOALX804064C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804064C100

Codice articolo locale: ENZOALX804064C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Codice catalogo: (ENZOADIAAP149E)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ADIAAP149E

Codice articolo locale: ENZOADIAAP149E

Descrizione: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

UOM: 1 * 100 µG

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Fornitore: ENZO LIFE SCIENCES

Descrizione: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.

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Fornitore: ENZO LIFE SCIENCES

Descrizione: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

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Fornitore: ENZO LIFE SCIENCES

Descrizione: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.

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Codice catalogo: (ENZOALX805711C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX805711C100

Codice articolo locale: ENZOALX805711C100

Descrizione: HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX805077C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX805077C100

Codice articolo locale: ENZOALX805077C100

Descrizione: CD66e (CEACAM5; CEA) belongs to the carcinoembryonic antigen (CEA) gene family. It encodes a glycosyl phosphatidyl inositol (GPI)-linked glycoprotein with a Mr of 180'000-200'000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cells of the tongue, esophagus and cervix. CD66e is used as a tumor marker for early detection of recurrent disease due to its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX805704C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX805704C100

Codice articolo locale: ENZOALX805704C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804278C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804278C100

Codice articolo locale: ENZOALX804278C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804144C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804144C100

Codice articolo locale: ENZOALX804144C100

Descrizione: Host: Mouse, Isotype: IgG1

UOM: 1 * 100 µG

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Codice catalogo: (ENZOALX804133C100)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX804133C100

Codice articolo locale: ENZOALX804133C100

Descrizione: Host: Human, Isotype: IgG1

UOM: 1 * 100 µG

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