Hai cercato: Biosensis

Fornitore: Biosensis

Descrizione: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.

Codice catalogo: (BSENBEK-2227)

Fornitore: Biosensis

Codice articolo fornitore: BEK-2227

Codice articolo locale: BSENBEK-2227

Descrizione: The Biosensis Multi-Neurotrophin Rapid™ Screening ELISA Kit has been designed to allow rapid screening and quantification of NGF, BDNF, NT3 and NT4/5 in cell culture supernatants, lysates, serum, plasma (EDTA and citrate) and brain extracts only if used as directed.

UOM: 1 * 192 Tests

Promo

Codice catalogo: (BSENPE-001-100)

Fornitore: Biosensis

Codice articolo fornitore: PE-001-100

Codice articolo locale: BSENPE-001-100

Descrizione: Saporin is a ribosome-inactivating protein (RIP) of type I. This monomeric RNA N-glycosidase purified from seeds of the plant Saponaria officinalis also known as Soapwort, is capable of specific depurination of eukaryotic ribosomes thus arresting protein synthesis. No ligand has been identified in saporin hence its inability to transverse the cell membrane. Due to its toxicity and stability of the structure, saporin has proven extremely useful for construction of immunotoxins.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1653-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1653-100

Codice articolo locale: BSENM-1653-100

Descrizione: Anti-MCHERRY Mouse T4 Antibody [clone: 1C51]

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1372-250)

Fornitore: Biosensis

Codice articolo fornitore: M-1372-250

Codice articolo locale: BSENM-1372-250

Descrizione: Fibrillarin is part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. This means that suitably cross-reactive antibodies to Nop1p/fibrillarin such as this antibody can be used to reveal nucleoli and study fibrillarin/Nop1p in all eukaryotes and archea tested to date. This antibody is becoming widely used as a convenient marker for nucleoli in a wide variety of species.

UOM: 1 * 250 µl

Promo

Codice catalogo: (BSENC-1371-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1371-100

Codice articolo locale: BSENC-1371-100

Descrizione: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (Reference: uniprot.org)

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-1654-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1654-100

Codice articolo locale: BSENR-1654-100

Descrizione: mCherry is an engineered derivative of one of a family of proteins originally isolated from Cnidarians (jelly fish, sea anemones and corals). The mCherry protein was derived from DsRed, a red fluorescent protein from so-called disc corals of the genus Discosoma. DsRed is a 223 amino acid ~28kDa protein similar in size and properties to GFP, but, obviously, produces a red rather than a green fluorochrome. The original DsRed was engineered extensively in the Tsien lab to prevent it from forming tetramers and dimers and to modify and improve the spectral properties (1-3). The resulting monomeric protein is useful for applications such as Förster Resonance Energy Transfer (FRET, also known as Fluorescence Resonance Energy Transfer). Several further cycles of mutation, directed modification and evolutionary selection produced mCherry, which is monomeric and has an excitation maximum at 587 nm and and emission maximum at 610 nm (4).

UOM: 1 * 100 µG

Promo

Fornitore: Biosensis

Descrizione: X63-saporin is an antibody conjugate comprising of the non-specific monoclonal IgG1 antibody X63, chemically conjugated via a reducible disulfide bridge to the ribosome-inactivating protein saporin, purified from saponaria officinalis. Antibody clone X63 has no known binding ability, and thus can be used as negative control antibody. In combination with saporin, X63-saporin is a useful negative control for targeting IgG1-saporin conjugates such as MC192-saporin.

Codice catalogo: (BSENC-1691-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1691-100

Codice articolo locale: BSENC-1691-100

Descrizione: FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. SUBCELLULAR LOCATION: Cytoplasm; cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENC-1541-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1541-100

Codice articolo locale: BSENC-1541-100

Descrizione: Transforming growth factor beta-1 (TGFB1) is a multi-functional cytokine with roles in proliferation, differentiation and other functions in many cell types. The secreted TGFB1 protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide (Ref: SWISS-Prot).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENM-1403-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1403-100

Codice articolo locale: BSENM-1403-100

Descrizione: TAR DNA-binding protein 43 (TDP43) is a DNA and RNA-binding protein which regulates transcription and splicing (ref: SWISSPROT).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENM-1576-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1576-100

Codice articolo locale: BSENM-1576-100

Descrizione: SF3B4 is one of 8 subunits of splicing factor SF3B. SF3B4 is ubiquitously expressed in the nuclei of eukaryotic cells, although it migrates into the cytoplasm of dividing cells.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENC-1539-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1539-100

Codice articolo locale: BSENC-1539-100

Descrizione: Peptide YY (PYY) is secreted from endocrine cells in the lower small intestine, colon and pancreas. PYY inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility (Ref: SWISS-Prot).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENM-1575-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1575-100

Codice articolo locale: BSENM-1575-100

Descrizione: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. The Spectrins form into dimers and further into tetramers of alpha and beta subunits (Ref: Entrez Gene). The alpha-II subunit is widely expressed in tissues but, in the nervous system, is found predominantly in neurons.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENC-1509-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1509-100

Codice articolo locale: BSENC-1509-100

Descrizione: C-reactive protein has several roles associated with host defence such as; promoting agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. C-reactive protein exists as a homopentamer. There are 2 alternatively spliced isoforms. C-reactive protein is found in plasma and its concentration increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENC-1527-100)

Fornitore: Biosensis

Codice articolo fornitore: C-1527-100

Codice articolo locale: BSENC-1527-100

Descrizione: Fatty acid-binding protein, adipocyte (ALBP) is a lipid transport protein which binds long chain fatty acids and other hydrophobic ligands and delivers them to their receptors in the nucleus. ALBP is found in the cytoplasm and nucleus of adipocytes.

UOM: 1 * 100 µl

Promo