Hai cercato: genome

Codice catalogo: (BOSSBS-5623R)

Fornitore: Bioss

Codice articolo fornitore: BS-5623R

Codice articolo locale: BOSSBS-5623R

Descrizione: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8176R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-8176R-CY5

Codice articolo locale: BOSSBS-8176R-CY5

Descrizione: The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3962R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-3962R-CY5.5

Codice articolo locale: BOSSBS-3962R-CY5.5

Descrizione: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1347R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-1347R-CY5.5

Codice articolo locale: BOSSBS-1347R-CY5.5

Descrizione: Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5623R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-5623R-CY5.5

Codice articolo locale: BOSSBS-5623R-CY5.5

Descrizione: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6395R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-6395R-CY7

Codice articolo locale: BOSSBS-6395R-CY7

Descrizione: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1347R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-1347R-CY5

Codice articolo locale: BOSSBS-1347R-CY5

Descrizione: Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7914R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-7914R-A680

Codice articolo locale: BOSSBS-7914R-A680

Descrizione: The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6109R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-6109R-FITC

Codice articolo locale: BOSSBS-6109R-FITC

Descrizione: SNF5 is involved in transcriptional activation. The SWI/SNF complex is required for the induced expression of a large number of genes. This complex alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors. SNF5 also funtions as a tumor suppressor gene and is frequently mutated in malignant rhabdoid tumors. It is also involved in adipocyte differentiation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0352R)

Fornitore: Bioss

Codice articolo fornitore: BS-0352R

Codice articolo locale: BOSSBS-0352R

Descrizione: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15526R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-15526R-A647

Codice articolo locale: BOSSBS-15526R-A647

Descrizione: This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0376R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-0376R-HRP

Codice articolo locale: BOSSBS-0376R-HRP

Descrizione: The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2473R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-2473R-A350

Codice articolo locale: BOSSBS-2473R-A350

Descrizione: This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. [provided by RefSeq].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6369R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-6369R-HRP

Codice articolo locale: BOSSBS-6369R-HRP

Descrizione: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15577R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-15577R-A750

Codice articolo locale: BOSSBS-15577R-A750

Descrizione: The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or are made. Two transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6905R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-6905R-A750

Codice articolo locale: BOSSBS-6905R-A750

Descrizione: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organisation. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

UOM: 1 * 100 µl

Promo