Hai cercato: genome

Codice catalogo: (BOSSBS-5828R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-5828R-CY3

Codice articolo locale: BOSSBS-5828R-CY3

Descrizione: Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. Protocadherin beta 13 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13555R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-13555R-FITC

Codice articolo locale: BOSSBS-13555R-FITC

Descrizione: ZBED5 contains 1 BED type zinc finger and it may be derived from an ancient transposon that has lost its ability to translocate. This gene is unusual in that its coding sequence is mostly derived from Charlie like DNA transposon. There is mRNA and EST evidence to suggest that this gene is transcribed. The encoded protein shares 70% identity with Charlie 1 transposase, however, this gene does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The exact function of this gene product is not known.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13555R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13555R-A680

Codice articolo locale: BOSSBS-13555R-A680

Descrizione: ZBED5 contains 1 BED type zinc finger and it may be derived from an ancient transposon that has lost its ability to translocate. This gene is unusual in that its coding sequence is mostly derived from Charlie like DNA transposon. There is mRNA and EST evidence to suggest that this gene is transcribed. The encoded protein shares 70% identity with Charlie 1 transposase, however, this gene does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The exact function of this gene product is not known.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13555R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-13555R-A350

Codice articolo locale: BOSSBS-13555R-A350

Descrizione: ZBED5 contains 1 BED type zinc finger and it may be derived from an ancient transposon that has lost its ability to translocate. This gene is unusual in that its coding sequence is mostly derived from Charlie like DNA transposon. There is mRNA and EST evidence to suggest that this gene is transcribed. The encoded protein shares 70% identity with Charlie 1 transposase, however, this gene does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The exact function of this gene product is not known.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13354R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-13354R-HRP

Codice articolo locale: BOSSBS-13354R-HRP

Descrizione: Growth hormone 2 (GH2) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. The major role of GH2 in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12157R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-12157R-A680

Codice articolo locale: BOSSBS-12157R-A680

Descrizione: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterised by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumour called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13354R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-13354R-A680

Codice articolo locale: BOSSBS-13354R-A680

Descrizione: Growth hormone 2 (GH2) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. The major role of GH2 in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6926R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-6926R-A647

Codice articolo locale: BOSSBS-6926R-A647

Descrizione: CCDC125, also known as KENAE, is a 511 amino acid protein expressed as two isoforms produced by alternative splicing and encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4501R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4501R-HRP

Codice articolo locale: BOSSBS-4501R-HRP

Descrizione: The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7995R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-7995R-HRP

Codice articolo locale: BOSSBS-7995R-HRP

Descrizione: This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7995R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-7995R-A555

Codice articolo locale: BOSSBS-7995R-A555

Descrizione: This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-7995R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-7995R-A350

Codice articolo locale: BOSSBS-7995R-A350

Descrizione: This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8026R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-8026R-CY5.5

Codice articolo locale: BOSSBS-8026R-CY5.5

Descrizione: This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. The protein encoded by this gene is highly expressed in leukocytes, but its exact function is unknown. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5827R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-5827R-CY7

Codice articolo locale: BOSSBS-5827R-CY7

Descrizione: PCDHGB5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5827R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-5827R-CY3

Codice articolo locale: BOSSBS-5827R-CY3

Descrizione: PCDHGB5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11292R)

Fornitore: Bioss

Codice articolo fornitore: BS-11292R

Codice articolo locale: BOSSBS-11292R

Descrizione: The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. HOX genes that occupy the same relative position along the 5’ to 3’ coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent HOX genes on the same chromosome. HoxA3, in conjunction with Pax1, mediates the development of the thymus, parathyroid gland, and carotid body. Its expression in the third pharyngeal arch and pouch is required for development of the third arch artery, and homozygous null HoxA3 mutants lack the carotid body. HoxA3 also regulates hindbrain development by controlling the axon projection pattern of motor neurons and sensory neurons of the proximal and distal ganglia.

UOM: 1 * 100 µl

Promo