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Image Unavailable-BOSSBS-0251R-HRP

Anti-RARA Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-0251R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-0251R-HRP
Codice articolo locale: BOSSBS-0251R-HRP
Descrizione: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0251R-A647

Anti-RARA Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-0251R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-0251R-A647
Codice articolo locale: BOSSBS-0251R-A647
Descrizione: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11785R-A350

Anti-SPG21 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-11785R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-11785R-A350
Codice articolo locale: BOSSBS-11785R-A350
Descrizione: Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11785R-FITC

Anti-SPG21 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-11785R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-11785R-FITC
Codice articolo locale: BOSSBS-11785R-FITC
Descrizione: Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
UOM: 1 * 100 µl
Image Unavailable-BNC680638-500

Anti-FGF23 Mouse Monoclonal Antibody (CF568) [clone: FGF23/638]

Fornitore: Biotium
Descrizione: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in trans- fected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Image Unavailable-BNC470638-500

Anti-FGF23 Mouse Monoclonal Antibody (CF647) [clone: FGF23/638]

Fornitore: Biotium
Descrizione: Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in trans- fected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Image Unavailable-BOSSBS-8333R-A555

Anti-RDH13 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-8333R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-8333R-A555
Codice articolo locale: BOSSBS-8333R-A555
Descrizione: RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8333R-CY5.5

Anti-RDH13 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-8333R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-8333R-CY5.5
Codice articolo locale: BOSSBS-8333R-CY5.5
Descrizione: RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11687R

Anti-PROSAAS Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-11687R)
Fornitore: Bioss
Codice articolo fornitore: BS-11687R
Codice articolo locale: BOSSBS-11687R
Descrizione: PCSK1N is a 260 amino acid protein that is both secreted and localized to the trans-Golgi network. Expressed in pancreas and brain, PCSK1N is thought to play a role in the control of the neuroendocrine secretory pathway and may also be involved in PCSK1 inhibition. The gene encoding PCSK1N maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination, as an X and a Y chromosome lead to normal male development, while two copies of an X chromosome lead to normal female development. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.
UOM: 1 * 100 µl
Product Image-BOSSBS-0251R

Anti-RARA Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-0251R)
Fornitore: Bioss
Codice articolo fornitore: BS-0251R
Codice articolo locale: BOSSBS-0251R
Descrizione: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-ICNA02190269.6

Retinoic acid all trans, yellow powder

Fornitore: MP Biomedicals
Descrizione: Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that mediates the functions of vitamin A required for growth and development. It affects gene transcription and modulates a wide variety of biological processes like Cell Proliferation, Differentiation, including Apoptosis. Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues

Image Unavailable-BOSSBS-0251R-A488

Anti-RARA Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-0251R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-0251R-A488
Codice articolo locale: BOSSBS-0251R-A488
Descrizione: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0251R-A555

Anti-RARA Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-0251R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-0251R-A555
Codice articolo locale: BOSSBS-0251R-A555
Descrizione: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11785R-CY5

Anti-SPG21 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-11785R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-11785R-CY5
Codice articolo locale: BOSSBS-11785R-CY5
Descrizione: Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11785R-A488

Anti-SPG21 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-11785R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-11785R-A488
Codice articolo locale: BOSSBS-11785R-A488
Descrizione: Maspardin is a 308 amino acid cytoplasmic protein that is widely expressed. Belonging to the AB hydrolase superfamily, Maspardin colocalizes with CD4 on endosomal/trans-Golgi network. It is thought that Maspardin may act as a negative regulatory factor in CD4-dependent T-cell activation. Defects in the gene encoding Maspardin are the result of hereditary spastic paraplegia autosomal recessive type 21 (also designated Mast syndrome), an autosomal recessive neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. The gene encoding Maspardin is encoded by human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.
UOM: 1 * 100 µl
Image Unavailable-CAYM29363-5

Long-Chain Cis/Trans Isomer Fatty Acid Methyl Ester Mixture

Codice catalogo: (CAYM29363-5)
Fornitore: Cayman Chemical
Codice articolo fornitore: 29363-5
Codice articolo locale: CAYM29363-5
Descrizione: Long-chain cis/trans isomer fatty acid methyl ester mixture contains cis and trans isomers of several fatty acids. It is intended for use as a reference standard for the detection of long-chain fatty acids in various sample types by GC-MS.
UOM: 1 * 5 mL

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