Hai cercato: s.o.c

Codice catalogo: (PE1354-1KT)

Fornitore: Merck

Codice articolo fornitore: PE1354-1KT

Codice articolo locale: SUPLPE1354-1KT

Descrizione: Regulated SOCS kit - WS, Supelco®, : N/A

UOM: 1 * 1 KIT

Promo

Codice catalogo: (BOSSBS-9134R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R-FITC

Codice articolo locale: BOSSBS-9134R-FITC

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9134R)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R

Codice articolo locale: BOSSBS-9134R

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9135R)

Fornitore: Bioss

Codice articolo fornitore: BS-9135R

Codice articolo locale: BOSSBS-9135R

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9135R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-9135R-CY5.5

Codice articolo locale: BOSSBS-9135R-CY5.5

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B and C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ASB-17 is a 295 amino acid member of this family. ASB-17 contains one ankyrin repeat and one SOCS box domain. ASB-17 is thought to be a substrate-recognition subunit of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination of target proteins and their subsequent proteasomal degradation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BWRLBS60384)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS60384

Codice articolo locale: BWRLBS60384

Descrizione: A synthetic peptide corresponding to residues in Human SOCS-3.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BOSSBS-7736R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-7736R-HRP

Codice articolo locale: BOSSBS-7736R-HRP

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the elongin B and C complex. Serveral other families of proteins also contain SOCS boxes but differ from the SOCS proteins in the type of domain they contained upstream of the SOCS box. Four members of the ankyrin repeat and SOCS box-containing (ASB) protein family are identified and termed as ASB-1, ASB-2, ASB-3 and ASB-4. ASB-1 is expressed in multiple organs, including the hematopoietic compartment. ASB-1 knock-out mice display a diminution of spermatogenesis with less complete filling of seminiferous tubules. Asb-2 is a novel retinoic-acid (RA)-induced gene in acute promyelocytic leukemia (APL) cells and its expression induces growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiaiton of APL cells. ASB-2 is directly induced by all-trans retinotic acid, by the binding of RARa to the RAR binding element/RXR binding element in the Asb-2 promoter.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BRDY813850)

Fornitore: Brady

Codice articolo fornitore: 813850

Codice articolo locale: BRDY813850

Descrizione: These chemical sorbent socs filled with chemical meltblown polypropylene that absorbs chemicals and hazardous liquids.

UOM: 1 * 12 pezzi

Promo

Codice catalogo: (USBIS1040-05L)

Fornitore: US Biological

Codice articolo fornitore: S1040-05L

Codice articolo locale: USBIS1040-05L

Descrizione: Anti-SOCS 5 Goat Polyclonal Antibody

UOM: 1 * 100 µG

Promo

Codice catalogo: (BOSSBS-13664R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-13664R-CY5

Codice articolo locale: BOSSBS-13664R-CY5

Descrizione: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9134R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R-CY7

Codice articolo locale: BOSSBS-9134R-CY7

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9134R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R-A488

Codice articolo locale: BOSSBS-9134R-A488

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9106R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-9106R-FITC

Codice articolo locale: BOSSBS-9106R-FITC

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-13 (ankyrin repeat and SOCS box-containing 13) is a 278 amino acid member of the ASB family that contains one SOCS box domain and six ANK repeats. Existing as multiple isoforms, ASB-13 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9134R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R-A350

Codice articolo locale: BOSSBS-9134R-A350

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9134R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-9134R-A750

Codice articolo locale: BOSSBS-9134R-A750

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-7 (ankyrin repeat and SOCS box-containing 7) is a 318 amino acid protein that contains one SOCS box domain and seven ANK repeats and belongs to the ASB family. Existing as multiple alternatively spliced isoforms, ASB-7 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9106R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-9106R-A750

Codice articolo locale: BOSSBS-9106R-A750

Descrizione: Members of the suppressor of cytokine signaling (SOCS) family of proteins contain C-terminal regions of homology called the SOCS box, which serves to couple SOCS proteins and their binding partners with the Elongin B/C complex. Several other families of proteins also contain SOCS boxes, but differ from the SOCS proteins in the type of domain they contain upstream of the SOCS box. The largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. ASB-13 (ankyrin repeat and SOCS box-containing 13) is a 278 amino acid member of the ASB family that contains one SOCS box domain and six ANK repeats. Existing as multiple isoforms, ASB-13 functions as a substrate-recognition component of an E3 ubiquitin-protein ligase complex and, working in conjunction with other proteins, plays a role in the ubiquitination and subsequent proteasomal degradation of target proteins.

UOM: 1 * 100 µl

Promo