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Image Unavailable-BOSSBS-3804R-HRP

Anti-MSH6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-3804R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-3804R-HRP
Codice articolo locale: BOSSBS-3804R-HRP
Descrizione: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3804R-A555

Anti-MSH6 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-3804R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-3804R-A555
Codice articolo locale: BOSSBS-3804R-A555
Descrizione: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3804R-CY7

Anti-MSH6 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-3804R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-3804R-CY7
Codice articolo locale: BOSSBS-3804R-CY7
Descrizione: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3804R-FITC

Anti-MSH6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-3804R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-3804R-FITC
Codice articolo locale: BOSSBS-3804R-FITC
Descrizione: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. Recruited on chromatin in G1 and early S phase via its PWWP domain that specifically binds trimethylated 'Lys-36' of histone H3 (H3K36me3): early recruitment to chromatin to be replicated allowing a quick identification of mismatch repair to initiate the DNA mismatch repair reaction.
UOM: 1 * 100 µl
Image Unavailable-MMMADT-1135E

Particulate Filter, DT

Codice catalogo: (MMMADT-1135E)
Fornitore: 3M
Codice articolo fornitore: DT-1135E
Codice articolo locale: MMMADT-1135E
Descrizione: For effective protection against a range of particulates, gases and vapours or combination hazards, use 3M™ filters DT-Series. Suitable for use with certain 3M™ half and full-face tight-fitting respirators in negative-pressure mode as well as 3M™ powered air respirator system PF-600E+ series.
UOM: 1 * 10 pezzi
Product Image-BOHLD512-02

Tubing distributors, BOLA

Fornitore: Bohlender
Descrizione: Tubing distributors, body made of PTFE with nuts made of glass-fibre reinforced PTFE. One inlet and three or four outlets, bore diameter 6 mmutors made of fluoroplastic with glass-fibre reinforced PTFE nuts.

Product Image-MFLX31608-22BLK

CPC® DrumQuik® PRO Drum Dispensing System Components

Fornitore: Avantor Fluid Handling
Descrizione: Closed-system design ensures the safety of your environment and employees - at all phases of chemical handling.

Product Image-129-3126

Autoclavable Muff Covers, DuPont™ Tyvek®

Fornitore: KEYSTONE CLEANROOM PRODUCTS
Descrizione: Save time and standardise the activities in equipment preparation for sterilisation.

Product Image-115-1596

Toilet paper, T6 - Compact, Tork

Fornitore: Essity
Descrizione: These high capacity rolls fit into the T6 Tork dispensers for compact twin rolls.

Product Image-7513-00

Accessori per processori di colonne SPE

Fornitore: Avantor
Descrizione: Coperchio, colore blu, nylon, con raccordi tipo Luer, per processore per colonne SPE-12G, J.T.Baker®

Certificati

Product Image-MMMA2060GB

Fast shine microfibre wipes, 2060 series, Scotch-Brite™

Fornitore: 3M
Descrizione: The 2060 series Scotch-Brite™ fast shine microfibre wipes are semi-disposable microfibre wipes with great cleaning properties. These wipes offer quick and effective cleaning performance when used with or without chemicals on most surfaces.

Product Image-111-0450

Tappi auricolari riutilizzabili, 1291, E-A-R™ Ultrafit™

Codice catalogo: (111-0450)
Fornitore: 3M
Codice articolo fornitore: UF01000
Codice articolo locale: MMMAUF01000
Descrizione: These earplugs are made from flexible materials that are already pre-formed to ensure optimum fit.
UOM: 1 * 50 PAIO
Product Image-MEMMB29741SF450

Accessories for steriliser SF 450

Fornitore: MEMMERT
Descrizione: Flush-fit unit(stainless steel frame covering gap between oven and wall opening), with air slots, Per: SF 450

Image Unavailable-MEMMUN160PAF7

Factory fitted options for Memmert UNpa series Paraffin ovens

Fornitore: MEMMERT
Descrizione: Factory fitted options for Memmert UNpa series Paraffin ovens

Product Image-620-2507

Water activity meter, AwTherm

Fornitore: ROTRONIC INSTRUMENTS
Descrizione: AwTherm is a temperature controlled water activity station – used for determining the water activity of a sample, maintained at a known temperature. Ideal to measure water activity in foodstuffs, cosmetics or pharmaceutical industries.

Product Image-630-8546

Clip-on magnifiers, laboCLIP

Fornitore: ESCHENBACH OPTIK
Descrizione: These clip-on magnifiers are designed to provide hands-free magnification, and fit most eyeglass frames.

Prezzo a richiesta
La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
Puoi ordinare questo prodotto. Se necessario, ti contatteremo per richiedere licenza, autorizzazione o dichiarazione d'uso per procedere con la fornitura.
Puoi ordinare questo prodotto. Se necessario, ti contatteremo per richiedere licenza, autorizzazione o dichiarazione d'uso per procedere con la fornitura.
Questo prodotto è stato bloccato dalla vostra organizzazione. Si prega di contattare il vostro responsabile acquisti per ulteriori informazioni.
Il prodotto originale non è più disponibile. L'articolo suggerito è disponibile
Il prodotto marcato con questo simbolo non è più disponibile o vendibile fino ad esaurimento scorte. Alternative possono essere disponibili utilizzando il numero di catalogo VWR. Per maggiori informazioni può contattare il nostro customer service al 023320311 o inviando una email all'indirizzo ebusiness.italy@avantorsciences.com
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