Hai cercato: Tyrphostin+AG+835

Codice catalogo: (BOSSBS-0177R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-0177R-HRP

Codice articolo locale: BOSSBS-0177R-HRP

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3872R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-3872R-A647

Codice articolo locale: BOSSBS-3872R-A647

Descrizione: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3872R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-3872R-A488

Codice articolo locale: BOSSBS-3872R-A488

Descrizione: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

UOM: 1 * 100 µl

Promo

Fornitore: THERMO FISHER DIAGNOSTICS

Descrizione: IMAGEN™ is a qualitative direct immunofluorescence test used for detection and confirmation of the presence of virus in cell culture or in clinical specimen.

Codice catalogo: (BOSSBS-5890R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-5890R-A350

Codice articolo locale: BOSSBS-5890R-A350

Descrizione: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5890R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5890R-A750

Codice articolo locale: BOSSBS-5890R-A750

Descrizione: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10283R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-10283R-FITC

Codice articolo locale: BOSSBS-10283R-FITC

Descrizione: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0517R)

Fornitore: Bioss

Codice articolo fornitore: BS-0517R

Codice articolo locale: BOSSBS-0517R

Descrizione: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4890R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-4890R-A488

Codice articolo locale: BOSSBS-4890R-A488

Descrizione: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4890R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4890R-HRP

Codice articolo locale: BOSSBS-4890R-HRP

Descrizione: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1449R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-1449R-A350

Codice articolo locale: BOSSBS-1449R-A350

Descrizione: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo

Fornitore: Schott AG

Descrizione: AR-Glas®, clear.

Fornitore: Schott AG

Descrizione: Vetro AR®, trasparente.

Codice catalogo: (BOSSBS-9314R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-9314R-A555

Codice articolo locale: BOSSBS-9314R-A555

Descrizione: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8362R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-8362R-A647

Codice articolo locale: BOSSBS-8362R-A647

Descrizione: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8362R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-8362R-FITC

Codice articolo locale: BOSSBS-8362R-FITC

Descrizione: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

UOM: 1 * 100 µl

Promo