Hai cercato: Tyrphostin+AG+835

Fornitore: SCHOTT AG Lighting and imaging

Descrizione: Illuminatori a luce fredda, Supporto per lente focalizzatrice (631-0009)

Codice catalogo: (BOSSBS-3872R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-3872R-HRP

Codice articolo locale: BOSSBS-3872R-HRP

Descrizione: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5890R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-5890R-A488

Codice articolo locale: BOSSBS-5890R-A488

Descrizione: Present in the extracellular matrix of human articular cartilage at all ages, although its abundance is far greater in the adult. In the adult cartilage lumican exists predominantly in a glycoprotein form lacking keratan sulfate, whereas the juvenile form of the molecule is a proteoglycan.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4890R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-4890R-CY5.5

Codice articolo locale: BOSSBS-4890R-CY5.5

Descrizione: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0177R-PE)

Fornitore: Bioss

Codice articolo fornitore: BS-0177R-PE

Codice articolo locale: BOSSBS-0177R-PE

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4890R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-4890R-A350

Codice articolo locale: BOSSBS-4890R-A350

Descrizione: Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0177R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-0177R-HRP

Codice articolo locale: BOSSBS-0177R-HRP

Descrizione: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides (By similarity). Interaction with S1B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10283R)

Fornitore: Bioss

Codice articolo fornitore: BS-10283R

Codice articolo locale: BOSSBS-10283R

Descrizione: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3541R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-3541R-A750

Codice articolo locale: BOSSBS-3541R-A750

Descrizione: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically Recognises phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3541R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-3541R-A680

Codice articolo locale: BOSSBS-3541R-A680

Descrizione: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically Recognises phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1449R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-1449R-A350

Codice articolo locale: BOSSBS-1449R-A350

Descrizione: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11348R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-11348R-A350

Codice articolo locale: BOSSBS-11348R-A350

Descrizione: Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0519R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-0519R-FITC

Codice articolo locale: BOSSBS-0519R-FITC

Descrizione: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-0519R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-0519R-CY5.5

Codice articolo locale: BOSSBS-0519R-CY5.5

Descrizione: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.

UOM: 1 * 100 µl

Promo

Codice catalogo: (USBIC5870-01M)

Fornitore: US Biological

Codice articolo fornitore: C5870-01M

Codice articolo locale: USBIC5870-01M

Descrizione: Anti-CLU Mouse Monoclonal Antibody [clone: 10K73]

UOM: 1 * 500 µG

Promo

Codice catalogo: (C80105-25G)

Fornitore: SIGMA ALDRICH MICROSCOPY

Codice articolo fornitore: C80105-25G

Codice articolo locale: SIAMC80105-25G

Descrizione: Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in <i>Escherichia coli</i>. It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line. It has been used to study the effect of chrysin on human ovarian cancer cells.

UOM: 1 * 25 g

Promo