Stampa…

Hai cercato: TWO-PRO\u2122+1


35 444  risultati sono stati trovati

Perfeziona la ricerca Seleziona per
SearchResultCount:"35444"

Sort Results

Visualizzazione a lista Nuova Visualizzazione

La tua valutazione

Image Unavailable-PRSI91-529

Human recombinant Carboxypeptidase A2 (from Cells)

Codice catalogo: (PRSI91-529)
Fornitore: ProSci Inc.
Codice articolo fornitore: 91-529
Codice articolo locale: PRSI91-529
Descrizione: Carboxypeptidase A2 (CPA) is a secreted pancreatic procarboxy-peptidase that cleaves the C-terminal amide or ester bond of peptides that have a free C-terminal carboxyl group. The hydrolytic action of CPA2 was identified with a preference towards long substrates with aromatic amino acids in their C-terminal end, particularly tryptophan. CPA2 comprises a signal peptide, a pro region and a mature chain, and can be activated after cleavage of the pro peptide. Three different forms of human pancreatic procarboxypeptidase A have been isolated, and the A1 and A2 forms are always secreted as monomeric proteins with different biochemical properties. In contrast to procarboxypeptidase B which was always secreted by the pancreas as a monomer, procarboxypeptidase A occurs as a monomer and/or associated to one or two functionally different proteins, such as zymogen E, and is involved in zymogen inhibition.
UOM: 1 * 50 µG
Image Unavailable-BOSSBS-0087R-A555

Anti-CASP3 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-0087R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-0087R-A555
Codice articolo locale: BOSSBS-0087R-A555
Descrizione: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0087R-A680

Anti-CASP3 Subunit p12 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-0087R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-0087R-A680
Codice articolo locale: BOSSBS-0087R-A680
Descrizione: The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesised as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2995R-CY7

Anti-MSK1/2 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-2995R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-2995R-CY7
Codice articolo locale: BOSSBS-2995R-CY7
Descrizione: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain. MSK2 plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
UOM: 1 * 100 µl
Product Image-PRSI96-543

Human recombinant Mesothelin 1 (from HEK293 cells)

Codice catalogo: (PRSI96-543)
Fornitore: ProSci Inc.
Codice articolo fornitore: 96-543
Codice articolo locale: PRSI96-543
Descrizione: Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
UOM: 1 * 100 µG
Product Image-PRSI96-545

Human recombinant Mesothelin (from HEK293 cells)

Codice catalogo: (PRSI96-545)
Fornitore: ProSci Inc.
Codice articolo fornitore: 96-545
Codice articolo locale: PRSI96-545
Descrizione: Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
UOM: 1 * 100 µG
Image Unavailable-521-1959

Accessories for Fiberlite™ Rotors

Fornitore: Thermo Fisher Scientific
Descrizione: Adapter, Oak ridge tube, 3×30 ml, for F12-6×500 rotor, set of two, Per: Fiberlite™ rotors

Product Image-BIND9051-0035

Accesories for CB170 CO₂ incubators

Codice catalogo: (BIND9051-0035)
Fornitore: Binder
Codice articolo fornitore: 9051-0035
Codice articolo locale: BIND9051-0035
Descrizione: Stacking adapter, Per: Direct thermal decoupled stacking of two CB 170 CO<sub>2</sub> incubators
UOM: 1 * 1 pezzi
Product Image-216-1665

Clips for 4" chip trays, H 44 Series

Fornitore: ENTEGRIS
Descrizione: Interlocking tabs press on the center of the tray for secure contact between the tray and cover.

Product Image-PRSI3351

Anti-BAX Rabbit Polyclonal Antibody

Codice catalogo: (PRSI3351)
Fornitore: ProSci Inc.
Codice articolo fornitore: 3351
Codice articolo locale: PRSI3351
Descrizione: Bax Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.
UOM: 1 * 100 µG
Image Unavailable-181-0506

VWR®, Accessories Rotary Vane Pumps, Two-Stage, RV+ Series

Fornitore: VWR Collection
Descrizione: Kit di manutenzione per VWR RV3+, con kit guarnizioni e palette

Image Unavailable-PRSI91-332

Human recombinant Kallikrein 11 (from Cells)

Codice catalogo: (PRSI91-332)
Fornitore: ProSci Inc.
Codice articolo fornitore: 91-332
Codice articolo locale: PRSI91-332
Descrizione: Human Kallikrein 11 (KLK11) is a member of tissue kallikrein family which are extracellular serine proteases consisting of 15 members. Two isoforms of KLK11 are differentially expressed. Isoform 1 is predominantly expressed in brain and isoform 2 is preferentially expressed in prostate. Isoform 1 consists of a signal peptide,a short pro peptide and the mature chain.Isoform 2 contains an extra 32 amino acid N terminal to full-length isoform 1.KLK11 is a novel marker for ovarian and prostate cancer carcinomas. KLK11 can be activated by thermolysin and is active against a thioester substrate.
UOM: 1 * 50 µG
Product Image-PRSIPM-4523

Anti-BBC3 Mouse Monoclonal Antibody [clone: 2A8F6 ]

Codice catalogo: (PRSIPM-4523)
Fornitore: ProSci Inc.
Codice articolo fornitore: PM-4523
Codice articolo locale: PRSIPM-4523
Descrizione: PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
UOM: 1 * 100 µG
Product Image-PRSIPM-4527

Anti-BBC3 Mouse Monoclonal Antibody [clone: 10C5G1 ]

Codice catalogo: (PRSIPM-4527)
Fornitore: ProSci Inc.
Codice articolo fornitore: PM-4527
Codice articolo locale: PRSIPM-4527
Descrizione: PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
UOM: 1 * 100 µG
Product Image-PRSI3041

Anti-PUMA Rabbit Polyclonal Antibody

Codice catalogo: (PRSI3041)
Fornitore: ProSci Inc.
Codice articolo fornitore: 3041
Codice articolo locale: PRSI3041
Descrizione: PUMA Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
UOM: 1 * 100 µG
Image Unavailable-TCIAR0238-1VIAL

rSRL-LecBeads [for GlcNAcβ(1-2)Man, Galβ(1-3)GalNAc]

Codice catalogo: (TCIAR0238-1VIAL)
Fornitore: TCI
Codice articolo fornitore: R0238-1VIAL
Codice articolo locale: TCIAR0238-1VIAL
Descrizione: The rSRL is an Escherichia coli recombinant of carbohydrate-binding protein (Lectin) derived from Sclerotium rolfsii. This lectin preferably binds to [GlcNAcβ(1-2)Man, Galβ(1-3)GalNAc] glycan epitopes by its two distinct carbohydrate-binding sites.
The LecBeads is a lectin-immobilized agarose which is capable of capturing glycoproteins via binding to its specific epitope(s), and it is prepared by a covalent coupling method between lectin and agarose.
The Lectin-catch method using LecBeads (as shown in Application tab) is available for selective separation of glycoconjugates (glycoproteins, glycolipids, and so on). This rSRL-LecBeads (1 ml gel) shows a binding capacity of about 7.5 mg or more agalacto human Transferrin [agalacto hTF] through its binding to a terminal [GlcNAcβ(1-2)Man] glycan epitope on agalacto hTF.
UOM: 1 * 1 Vial
Prezzo a richiesta
La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
Puoi ordinare questo prodotto. Se necessario, ti contatteremo per richiedere licenza, autorizzazione o dichiarazione d'uso per procedere con la fornitura.
Puoi ordinare questo prodotto. Se necessario, ti contatteremo per richiedere licenza, autorizzazione o dichiarazione d'uso per procedere con la fornitura.
Questo prodotto è stato bloccato dalla vostra organizzazione. Si prega di contattare il vostro responsabile acquisti per ulteriori informazioni.
Il prodotto originale non è più disponibile. L'articolo suggerito è disponibile
Il prodotto marcato con questo simbolo non è più disponibile o vendibile fino ad esaurimento scorte. Alternative possono essere disponibili utilizzando il numero di catalogo VWR. Per maggiori informazioni può contattare il nostro customer service al 023320311 o inviando una email all'indirizzo ebusiness.italy@avantorsciences.com
177 - 192 of 35 444
no targeter for Bottom