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Image Unavailable-BOSSBS-3412R-A750

Anti-SHC Tyr427 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-3412R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-3412R-A750
Codice articolo locale: BOSSBS-3412R-A750
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10516R-A488

Anti-CALCR Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-10516R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-10516R-A488
Codice articolo locale: BOSSBS-10516R-A488
Descrizione: This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
UOM: 1 * 100 µl
Image Unavailable-BNC400964-100

Anti-CD47 Mouse Monoclonal Antibody (CF640R) [clone: IAP/964]

Fornitore: Biotium
Descrizione: This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.

Image Unavailable-BNUB1029-100

Anti-CD47 Mouse Monoclonal Antibody [clone: IAP/964 B6H12.2]

Fornitore: Biotium
Descrizione: This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.

Image Unavailable-BOSSBS-6096R-HRP

Anti-RNF139 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-6096R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-6096R-HRP
Codice articolo locale: BOSSBS-6096R-HRP
Descrizione: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6096R-A750

Anti-RNF139 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-6096R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-6096R-A750
Codice articolo locale: BOSSBS-6096R-A750
Descrizione: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6096R-A350

Anti-RNF139 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-6096R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-6096R-A350
Codice articolo locale: BOSSBS-6096R-A350
Descrizione: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3410R-CY3

Anti-SHC1 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-3410R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-3410R-CY3
Codice articolo locale: BOSSBS-3410R-CY3
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3410R-FITC

Anti-SHC1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-3410R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-3410R-FITC
Codice articolo locale: BOSSBS-3410R-FITC
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3410R-A750

Anti-SHC Ser36 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-3410R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-3410R-A750
Codice articolo locale: BOSSBS-3410R-A750
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3412R-A680

Anti-SHC Tyr427 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-3412R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-3412R-A680
Codice articolo locale: BOSSBS-3412R-A680
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3410R-A680

Anti-SHC Ser36 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-3410R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-3410R-A680
Codice articolo locale: BOSSBS-3410R-A680
Descrizione: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6096R

Anti-RNF139 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-6096R)
Fornitore: Bioss
Codice articolo fornitore: BS-6096R
Codice articolo locale: BOSSBS-6096R
Descrizione: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
UOM: 1 * 100 µl
Image Unavailable-20338-500UL

Anti-IgG Chicken Polyclonal Antibody (CF™ 568)

Codice catalogo: (20338-500UL)
Fornitore: Biotium
Codice articolo fornitore: 20338-500UL
Codice articolo locale: BTIU20338-500UL
Descrizione: CF™568 antibodies are affinity-purified antibodies labeled with red fluorescent CF™568, a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.
UOM: 1 * 0,5 mL
Image Unavailable-20366-500UL

Anti-IgG Goat Polyclonal Antibody (CF™ 532)

Codice catalogo: (20366-500UL)
Fornitore: Biotium
Codice articolo fornitore: 20366-500UL
Codice articolo locale: BTIU20366-500UL
Descrizione: CF™532 antibodies are affinity-purified antibodies labeled with orange fluorescent CF™532 (Ex/Em: 527/558nm), a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.
UOM: 1 * 0,5 mL
Image Unavailable-20333-500UL

Anti-IgG Chicken Polyclonal Antibody (CF™ 543)

Codice catalogo: (20333-500UL)
Fornitore: Biotium
Codice articolo fornitore: 20333-500UL
Codice articolo locale: BTIU20333-500UL
Descrizione: CF™543 antibodies are affinity-purified antibodies labeled with orange fluorescent CF™543 (Ex/Em 541/560nm), a member of the novel CF™ dye series developed by Biotium for labeling proteins and other biomolecules. CF™ dyes are designed to offer advantages in brightness, photostability, and/or specificity compared to other commercial dyes, and are available in colors spanning the visible, far-red, and near-infrared spectra.
UOM: 1 * 0,5 mL
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