Hai cercato: SHP+Steriltechnik

Codice catalogo: (PRSI30-252)

Fornitore: ProSci Inc.

Codice articolo fornitore: 30-252

Codice articolo locale: PRSI30-252

Descrizione: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI26-179)

Fornitore: ProSci Inc.

Codice articolo fornitore: 26-179

Codice articolo locale: PRSI26-179

Descrizione: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI96-002)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-002

Codice articolo locale: PRSI96-002

Descrizione: Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI96-001)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-001

Codice articolo locale: PRSI96-001

Descrizione: Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI91-439)

Fornitore: ProSci Inc.

Codice articolo fornitore: 91-439

Codice articolo locale: PRSI91-439

Descrizione: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI26-494)

Fornitore: ProSci Inc.

Codice articolo fornitore: 26-494

Codice articolo locale: PRSI26-494

Descrizione: SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI92-390)

Fornitore: ProSci Inc.

Codice articolo fornitore: 92-390

Codice articolo locale: PRSI92-390

Descrizione: Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signalling induced by ConA, which probably includes Src family tyrosine-protein kinases.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI96-118)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-118

Codice articolo locale: PRSI96-118

Descrizione: T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI96-694)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-694

Codice articolo locale: PRSI96-694

Descrizione: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI96-695)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-695

Codice articolo locale: PRSI96-695

Descrizione: Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BOSSBS-1233R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-1233R-A680

Codice articolo locale: BOSSBS-1233R-A680

Descrizione: SHP-2/PTPN11 POLYCLONAL ANTIBODY, AF680 1 * 100 µl

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-1233R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-1233R-A750

Codice articolo locale: BOSSBS-1233R-A750

Descrizione: SHP-2/PTPN11 POLYCLONAL ANTIBODY, AF750 1 * 100 µl

UOM: 1 * 100 µl

Promo

Codice catalogo: (SHPS5005-10000-996)

Fornitore: SHP Steriltechnik

Codice articolo fornitore: 5005-10000-996

Codice articolo locale: SHPS5005-10000-996

Descrizione: [EN]SPARE PART KIT SHP 80 B 1 * 1 KIT

UOM: 1 * 1 KIT

Promo

Codice catalogo: (SHPS5005-10000-159)

Fornitore: SHP Steriltechnik

Codice articolo fornitore: 5005-10000-159

Codice articolo locale: SHPS5005-10000-159

Descrizione: [EN]COUPLING G 3/8-G 1/4 1 * 1 pezzi

UOM: 1 * 1 pezzi

Promo

Codice catalogo: (SHPS5005-10000-029)

Fornitore: SHP Steriltechnik

Codice articolo fornitore: 5005-10000-029

Codice articolo locale: SHPS5005-10000-029

Descrizione: [EN]FOOT 1 * 1 pezzi

UOM: 1 * 1 pezzi

Promo

Codice catalogo: (SHPS290000000161)

Fornitore: SHP Steriltechnik

Codice articolo fornitore: 290000000161

Codice articolo locale: SHPS290000000161

Descrizione: [EN]BEARING 1 * 1 pezzi

UOM: 1 * 1 pezzi

Promo