Hai cercato: N-Carbobenzoxy-L-tyrosine

Codice catalogo: (BOSSBS-5453R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5453R-A680

Codice articolo locale: BOSSBS-5453R-A680

Descrizione: The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-15500R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-15500R-A488

Codice articolo locale: BOSSBS-15500R-A488

Descrizione: LTK is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13667R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-13667R-A488

Codice articolo locale: BOSSBS-13667R-A488

Descrizione: Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues (1,2). Kinases are capable of influencing the oncogenic potential of cell sytems at the level of oncoprotein or tumor suppressor protein phosphorylation states (1,2). STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK (3). BRK (breast tumor kinase, Sik) is a 451 amino acid, nonreceptor protein-tyrosine kinase that is overexpressed in breast tumors and metastatic melanoma cell lines (4). Similar to the Src family of intracellular kinses, BRK is comprised of an SH3 domain, an SH2 domain, and a catalytic domain (5). STAP-2 is susceptiple to tyrosine phosphorylation and may be invovled in tyrosine kinase-mediated signaling cascades, whose aberrant function may lead to metastis (3).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13699R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13699R-A647

Codice articolo locale: BOSSBS-13699R-A647

Descrizione: Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13699R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-13699R-A750

Codice articolo locale: BOSSBS-13699R-A750

Descrizione: Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13699R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-13699R-CY3

Codice articolo locale: BOSSBS-13699R-CY3

Descrizione: Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5400R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5400R-A680

Codice articolo locale: BOSSBS-5400R-A680

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukaemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12914R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-12914R-A750

Codice articolo locale: BOSSBS-12914R-A750

Descrizione: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumour growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumour, acute myeloid leukaemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12574R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-12574R-A680

Codice articolo locale: BOSSBS-12574R-A680

Descrizione: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell Signalling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing Signalling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12574R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12574R-A350

Codice articolo locale: BOSSBS-12574R-A350

Descrizione: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12574R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-12574R-A488

Codice articolo locale: BOSSBS-12574R-A488

Descrizione: p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10406R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-10406R-CY3

Codice articolo locale: BOSSBS-10406R-CY3

Descrizione: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6850R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6850R-CY3

Codice articolo locale: BOSSBS-6850R-CY3

Descrizione: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6850R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-6850R-CY5

Codice articolo locale: BOSSBS-6850R-CY5

Descrizione: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6271R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-6271R-CY3

Codice articolo locale: BOSSBS-6271R-CY3

Descrizione: Probable receptor with tyrosine-protein kinase activity; important for development.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6850R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-6850R-CY7

Codice articolo locale: BOSSBS-6850R-CY7

Descrizione: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides.

UOM: 1 * 100 µl

Promo